An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>
The discovery of eco-friendly, rapid, and cost-effective compounds to control diseases caused by microbes and insects are the main challenges. Herein, the magnesium oxide nanoparticles (MgO-NPs) are successfully fabricated by harnessing the metabolites secreted by <i>Penicillium chrysogenum<...
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2021-05-01
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author | Amr Fouda Mohamed A. Awad Ahmed M. Eid Ebrahim Saied Mohammed G. Barghoth Mohammed F. Hamza Mohamed F. Awad Salah Abdelbary Saad El-Din Hassan |
author_facet | Amr Fouda Mohamed A. Awad Ahmed M. Eid Ebrahim Saied Mohammed G. Barghoth Mohammed F. Hamza Mohamed F. Awad Salah Abdelbary Saad El-Din Hassan |
author_sort | Amr Fouda |
collection | DOAJ |
description | The discovery of eco-friendly, rapid, and cost-effective compounds to control diseases caused by microbes and insects are the main challenges. Herein, the magnesium oxide nanoparticles (MgO-NPs) are successfully fabricated by harnessing the metabolites secreted by <i>Penicillium chrysogenum</i>. The fabricated MgO-NPs were characterized using UV-Vis, XRD, TEM, DLS, EDX, FT-IR, and XPS analyses. Data showed the successful formation of crystallographic, spherical, well-dispersed MgO-NPs with sizes of 7–40 nm at a maximum wavelength of 250 nm. The EDX analysis confirms the presence of Mg and O ions as the main components with weight percentages of 13.62% and 7.76%, respectively. The activity of MgO-NPs as an antimicrobial agent was investigated against pathogens <i>Staphylococcus aureus</i>, <i>Bacillus subtilis</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i>, and exhibited zone of inhibitions of 12.0 ± 0.0, 12.7 ± 0.9, 23.3 ± 0.8, 17.7 ± 1.6, and 14.7 ± 0.6 mm respectively, at 200 µg mL<sup>−1</sup>. The activity is decreased by decreasing the MgO-NPs concentration. The biogenic MgO-NPs exhibit high efficacy against different larvae instar and pupa of <i>Anopheles stephensi</i>, with LC50 values of 12.5–15.5 ppm for I–IV larvae instar and 16.5 ppm for the pupa. Additionally, 5 mg/cm<sup>2</sup> of MgO-NPs showed the highest protection percentages against adults of <i>Anopheles stephensi</i>, with values of 100% for 150 min and 67.6% ± 1.4% for 210 min. |
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spelling | doaj.art-3f3781806d2f46b7b1d33dc56d6b13852023-11-21T19:16:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012210509610.3390/ijms22105096An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>Amr Fouda0Mohamed A. Awad1Ahmed M. Eid2Ebrahim Saied3Mohammed G. Barghoth4Mohammed F. Hamza5Mohamed F. Awad6Salah Abdelbary7Saad El-Din Hassan8Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Zoology and Entomology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptGuangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured Materials, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, ChinaDepartment of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptThe discovery of eco-friendly, rapid, and cost-effective compounds to control diseases caused by microbes and insects are the main challenges. Herein, the magnesium oxide nanoparticles (MgO-NPs) are successfully fabricated by harnessing the metabolites secreted by <i>Penicillium chrysogenum</i>. The fabricated MgO-NPs were characterized using UV-Vis, XRD, TEM, DLS, EDX, FT-IR, and XPS analyses. Data showed the successful formation of crystallographic, spherical, well-dispersed MgO-NPs with sizes of 7–40 nm at a maximum wavelength of 250 nm. The EDX analysis confirms the presence of Mg and O ions as the main components with weight percentages of 13.62% and 7.76%, respectively. The activity of MgO-NPs as an antimicrobial agent was investigated against pathogens <i>Staphylococcus aureus</i>, <i>Bacillus subtilis</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i>, and exhibited zone of inhibitions of 12.0 ± 0.0, 12.7 ± 0.9, 23.3 ± 0.8, 17.7 ± 1.6, and 14.7 ± 0.6 mm respectively, at 200 µg mL<sup>−1</sup>. The activity is decreased by decreasing the MgO-NPs concentration. The biogenic MgO-NPs exhibit high efficacy against different larvae instar and pupa of <i>Anopheles stephensi</i>, with LC50 values of 12.5–15.5 ppm for I–IV larvae instar and 16.5 ppm for the pupa. Additionally, 5 mg/cm<sup>2</sup> of MgO-NPs showed the highest protection percentages against adults of <i>Anopheles stephensi</i>, with values of 100% for 150 min and 67.6% ± 1.4% for 210 min.https://www.mdpi.com/1422-0067/22/10/5096green synthesisMgO-NPspathogenic microbes<i>Anopheles stephensi</i>biocontrolmosquitocidal |
spellingShingle | Amr Fouda Mohamed A. Awad Ahmed M. Eid Ebrahim Saied Mohammed G. Barghoth Mohammed F. Hamza Mohamed F. Awad Salah Abdelbary Saad El-Din Hassan An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i> International Journal of Molecular Sciences green synthesis MgO-NPs pathogenic microbes <i>Anopheles stephensi</i> biocontrol mosquitocidal |
title | An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i> |
title_full | An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i> |
title_fullStr | An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i> |
title_full_unstemmed | An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i> |
title_short | An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i> |
title_sort | eco friendly approach to the control of pathogenic microbes and i anopheles stephensi i malarial vector using magnesium oxide nanoparticles mg nps fabricated by i penicillium chrysogenum i |
topic | green synthesis MgO-NPs pathogenic microbes <i>Anopheles stephensi</i> biocontrol mosquitocidal |
url | https://www.mdpi.com/1422-0067/22/10/5096 |
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