Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study
BackgroundMany previous studies have revealed a close relationship between lipoprotein metabolism and sepsis, but their causal relationship has, until now, remained unclear. Therefore, we performed a two-sample Mendelian randomization analysis to estimate the causal relationship of lipoprotein-assoc...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1275132/full |
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| author | Liying Zeng Haoxuan Tang Jiehai Chen Yijian Deng Yunfeng Zhao Hang Lei Yufei Wan Ying Pan Yongqiang Deng |
| author_facet | Liying Zeng Haoxuan Tang Jiehai Chen Yijian Deng Yunfeng Zhao Hang Lei Yufei Wan Ying Pan Yongqiang Deng |
| author_sort | Liying Zeng |
| collection | DOAJ |
| description | BackgroundMany previous studies have revealed a close relationship between lipoprotein metabolism and sepsis, but their causal relationship has, until now, remained unclear. Therefore, we performed a two-sample Mendelian randomization analysis to estimate the causal relationship of lipoprotein-associated phospholipids with the risk of sepsis.Materials and methodsA two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship between lipoprotein-associated phospholipids and sepsis based on large-scale genome-wide association study (GWAS) summary statistics. MR analysis was performed using a variety of methods, including inverse variance weighted as the primary method, MR Egger, weighted median, simple mode, and weighted mode as complementary methods. Further sensitivity analyses were used to test the robustness of the data.ResultsAfter Bonferroni correction, the results of the MR analysis showed that phospholipids in medium high-density lipoprotein (HDL; ORIVW = 0.82, 95% CI 0.71-0.95, P = 0.0075), large HDL (ORIVW = 0.92, 95% CI 0.85-0.98, P = 0.0148), and very large HDL (ORMR Egger = 0.83, 95% CI 0.72-0.95, P = 0.0134) had suggestive causal relationship associations with sepsis. Sensitivity testing confirmed the accuracy of these findings. There was no clear association between other lipoprotein-associated phospholipids and sepsis risk.ConclusionsOur MR analysis data suggestively showed a correlation between higher levels of HDL-associated phospholipids and reduced risk of sepsis. Further studies are required to determine the underlying mechanisms behind this relationship. |
| first_indexed | 2024-03-08T14:47:50Z |
| format | Article |
| id | doaj.art-3f37b95350364ed29b260575ecae8e59 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T14:47:50Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-3f37b95350364ed29b260575ecae8e592024-01-11T05:24:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12751321275132Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization studyLiying Zeng0Haoxuan Tang1Jiehai Chen2Yijian Deng3Yunfeng Zhao4Hang Lei5Yufei Wan6Ying Pan7Yongqiang Deng8Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Precision Anaesthesia and Perioperative Organ Protection, Guangzhou, Guangdong, ChinaSchool of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, ChinaBackgroundMany previous studies have revealed a close relationship between lipoprotein metabolism and sepsis, but their causal relationship has, until now, remained unclear. Therefore, we performed a two-sample Mendelian randomization analysis to estimate the causal relationship of lipoprotein-associated phospholipids with the risk of sepsis.Materials and methodsA two-sample Mendelian randomization (MR) analysis was performed to investigate the causal relationship between lipoprotein-associated phospholipids and sepsis based on large-scale genome-wide association study (GWAS) summary statistics. MR analysis was performed using a variety of methods, including inverse variance weighted as the primary method, MR Egger, weighted median, simple mode, and weighted mode as complementary methods. Further sensitivity analyses were used to test the robustness of the data.ResultsAfter Bonferroni correction, the results of the MR analysis showed that phospholipids in medium high-density lipoprotein (HDL; ORIVW = 0.82, 95% CI 0.71-0.95, P = 0.0075), large HDL (ORIVW = 0.92, 95% CI 0.85-0.98, P = 0.0148), and very large HDL (ORMR Egger = 0.83, 95% CI 0.72-0.95, P = 0.0134) had suggestive causal relationship associations with sepsis. Sensitivity testing confirmed the accuracy of these findings. There was no clear association between other lipoprotein-associated phospholipids and sepsis risk.ConclusionsOur MR analysis data suggestively showed a correlation between higher levels of HDL-associated phospholipids and reduced risk of sepsis. Further studies are required to determine the underlying mechanisms behind this relationship.https://www.frontiersin.org/articles/10.3389/fendo.2023.1275132/fulllipoprotein-associated phospholipidssepsisMendelian randomizationcausal relationshipgenetics |
| spellingShingle | Liying Zeng Haoxuan Tang Jiehai Chen Yijian Deng Yunfeng Zhao Hang Lei Yufei Wan Ying Pan Yongqiang Deng Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study Frontiers in Endocrinology lipoprotein-associated phospholipids sepsis Mendelian randomization causal relationship genetics |
| title | Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study |
| title_full | Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study |
| title_fullStr | Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study |
| title_full_unstemmed | Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study |
| title_short | Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study |
| title_sort | causal association of lipoprotein associated phospholipids on the risk of sepsis a mendelian randomization study |
| topic | lipoprotein-associated phospholipids sepsis Mendelian randomization causal relationship genetics |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1275132/full |
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