Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis
Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.027971 |
| _version_ | 1797866353456054272 |
|---|---|
| author | Laura Ueberham Andreas Hagendorff Karin Klingel Ingo Paetsch Cosima Jahnke Theresa Kluge Hans Ebbinghaus Gerhard Hindricks Ulrich Laufs Borislav Dinov |
| author_facet | Laura Ueberham Andreas Hagendorff Karin Klingel Ingo Paetsch Cosima Jahnke Theresa Kluge Hans Ebbinghaus Gerhard Hindricks Ulrich Laufs Borislav Dinov |
| author_sort | Laura Ueberham |
| collection | DOAJ |
| description | Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic pitfalls, there are controversies in the understanding of the causes, genetic and environmental background, and the natural evolution of the disease. Here, we review the current pathophysiological aspects and gaps that are relevant for future cardiac sarcoidosis diagnostics and research. |
| first_indexed | 2024-04-09T23:22:47Z |
| format | Article |
| id | doaj.art-3f3d68e298aa4d388689470a658a7342 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T23:22:47Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-3f3d68e298aa4d388689470a658a73422023-03-21T11:45:26ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-03-0112610.1161/JAHA.122.027971Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac SarcoidosisLaura Ueberham0Andreas Hagendorff1Karin Klingel2Ingo Paetsch3Cosima Jahnke4Theresa Kluge5Hans Ebbinghaus6Gerhard Hindricks7Ulrich Laufs8Borislav Dinov9Klinik und Poliklinik für Kardiologie Universitätsklinikum Leipzig Leipzig GermanyKlinik und Poliklinik für Kardiologie Universitätsklinikum Leipzig Leipzig GermanyCardiopathology Institute for Pathology, Eberhard Karls Universität Tübingen Tübingen GermanyDepartment of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig GermanyDepartment of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig GermanyKlinik und Poliklinik für Nuklearmedizin Universitätsklinikum Leipzig Leipzig GermanyDepartment of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig GermanyDepartment of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig GermanyKlinik und Poliklinik für Kardiologie Universitätsklinikum Leipzig Leipzig GermanyDepartment of Electrophysiology Heart Center Leipzig at University of Leipzig Leipzig GermanyCardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic pitfalls, there are controversies in the understanding of the causes, genetic and environmental background, and the natural evolution of the disease. Here, we review the current pathophysiological aspects and gaps that are relevant for future cardiac sarcoidosis diagnostics and research.https://www.ahajournals.org/doi/10.1161/JAHA.122.027971cardiac inflammatory diseasecardiac sarcoidosismyocarditissarcoidosis diagnostic criteria |
| spellingShingle | Laura Ueberham Andreas Hagendorff Karin Klingel Ingo Paetsch Cosima Jahnke Theresa Kluge Hans Ebbinghaus Gerhard Hindricks Ulrich Laufs Borislav Dinov Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiac inflammatory disease cardiac sarcoidosis myocarditis sarcoidosis diagnostic criteria |
| title | Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis |
| title_full | Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis |
| title_fullStr | Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis |
| title_full_unstemmed | Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis |
| title_short | Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis |
| title_sort | pathophysiological gaps diagnostic challenges and uncertainties in cardiac sarcoidosis |
| topic | cardiac inflammatory disease cardiac sarcoidosis myocarditis sarcoidosis diagnostic criteria |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.027971 |
| work_keys_str_mv | AT lauraueberham pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT andreashagendorff pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT karinklingel pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT ingopaetsch pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT cosimajahnke pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT theresakluge pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT hansebbinghaus pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT gerhardhindricks pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT ulrichlaufs pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis AT borislavdinov pathophysiologicalgapsdiagnosticchallengesanduncertaintiesincardiacsarcoidosis |