Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report
Abstract Angiomatoid fibrosis histiocytoma (AFH) is a rare neoplastic disease. Only one report has demonstrated an intraluminal tumor of the pulmonary artery (PA) corresponding to AFH to date. We describe the case of AFH with EWSR1‐CREB1 fusion occurring in the ascending artery. A 42‐year‐old man ex...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.13929 |
| _version_ | 1819320032105070592 |
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| author | Shuji Mishima Osamu Mishima Koji Azuhata Hisashi Shimojo Nobuo Ito Kenji Misawa Kimihiro Shimizu |
| author_facet | Shuji Mishima Osamu Mishima Koji Azuhata Hisashi Shimojo Nobuo Ito Kenji Misawa Kimihiro Shimizu |
| author_sort | Shuji Mishima |
| collection | DOAJ |
| description | Abstract Angiomatoid fibrosis histiocytoma (AFH) is a rare neoplastic disease. Only one report has demonstrated an intraluminal tumor of the pulmonary artery (PA) corresponding to AFH to date. We describe the case of AFH with EWSR1‐CREB1 fusion occurring in the ascending artery. A 42‐year‐old man exhibited an abnormal nodule on chest computed tomography (CT) during checkup. It revealed an intraluminal mass in the ascending artery with significant metabolic uptake in positron emission tomography (PET)/CT. Therefore, right upper lobectomy with wedge resection of the PA trunk was performed. Histologically, the tumor was multinodular and surrounded by a dense lymphoplasmacytic cuff. Each nodule was composed of myxoid stroma and comprised ovoid or spindle cell fascicles with mild atypia. Fluorescent in situ hybridization (FISH) analysis confirmed EWSR1‐CREB1 fusion. A diagnosed as AFH was made. This report widens the spectrum of differential diagnoses of primary tumors occurring in the PA. |
| first_indexed | 2024-12-24T11:13:07Z |
| format | Article |
| id | doaj.art-3f3db651a369422d9805cb933b078cb9 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-24T11:13:07Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-3f3db651a369422d9805cb933b078cb92022-12-21T16:58:27ZengWileyThoracic Cancer1759-77061759-77142021-05-011291453145610.1111/1759-7714.13929Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case reportShuji Mishima0Osamu Mishima1Koji Azuhata2Hisashi Shimojo3Nobuo Ito4Kenji Misawa5Kimihiro Shimizu6Department of General Surgery Aizawa Hospital Matsumoto JapanDepartment of General Surgery Aizawa Hospital Matsumoto JapanDepartment of Anatomic Pathology Aizawa Hospital Matsumoto JapanDepartment of Anatomic Pathology Aizawa Hospital Matsumoto JapanDepartment of Anatomic Pathology Aizawa Hospital Matsumoto JapanDepartment of General Surgery Aizawa Hospital Matsumoto JapanDivision of General Thoracic Surgery, Department of Surgery Shinshu University School of Medicine Matsumoto JapanAbstract Angiomatoid fibrosis histiocytoma (AFH) is a rare neoplastic disease. Only one report has demonstrated an intraluminal tumor of the pulmonary artery (PA) corresponding to AFH to date. We describe the case of AFH with EWSR1‐CREB1 fusion occurring in the ascending artery. A 42‐year‐old man exhibited an abnormal nodule on chest computed tomography (CT) during checkup. It revealed an intraluminal mass in the ascending artery with significant metabolic uptake in positron emission tomography (PET)/CT. Therefore, right upper lobectomy with wedge resection of the PA trunk was performed. Histologically, the tumor was multinodular and surrounded by a dense lymphoplasmacytic cuff. Each nodule was composed of myxoid stroma and comprised ovoid or spindle cell fascicles with mild atypia. Fluorescent in situ hybridization (FISH) analysis confirmed EWSR1‐CREB1 fusion. A diagnosed as AFH was made. This report widens the spectrum of differential diagnoses of primary tumors occurring in the PA.https://doi.org/10.1111/1759-7714.13929angiomatoid fibrosis histiocytomacase reportEWSR1‐CREB1 fusionpulmonary artery |
| spellingShingle | Shuji Mishima Osamu Mishima Koji Azuhata Hisashi Shimojo Nobuo Ito Kenji Misawa Kimihiro Shimizu Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report Thoracic Cancer angiomatoid fibrosis histiocytoma case report EWSR1‐CREB1 fusion pulmonary artery |
| title | Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report |
| title_full | Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report |
| title_fullStr | Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report |
| title_full_unstemmed | Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report |
| title_short | Angiomatoid fibrosis histiocytoma in the pulmonary artery: A case report |
| title_sort | angiomatoid fibrosis histiocytoma in the pulmonary artery a case report |
| topic | angiomatoid fibrosis histiocytoma case report EWSR1‐CREB1 fusion pulmonary artery |
| url | https://doi.org/10.1111/1759-7714.13929 |
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