Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science
Abstract Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activit...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-05-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.2108 |
| _version_ | 1826978835301662720 |
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| author | Yuening Xiang Zimu Guo Pengfei Zhu Jia Chen Yongye Huang |
| author_facet | Yuening Xiang Zimu Guo Pengfei Zhu Jia Chen Yongye Huang |
| author_sort | Yuening Xiang |
| collection | DOAJ |
| description | Abstract Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activity of TCM, especially that of the Chinese herbal medicine‐derived phytochemicals curcumin, resveratrol, and berberine. Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. In addition, the impact of TCM treatment on DNA methylation, histone modification, and the regulation of noncoding RNAs is discussed. Furthermore, we have highlighted studies of TCM therapy that modulate the tumor microenvironment and eliminate cancer stem cells. The information compiled in this review will serve as a solid foundation to formulate hypotheses for future studies on TCM‐based cancer therapy. |
| first_indexed | 2024-04-24T17:11:31Z |
| format | Article |
| id | doaj.art-3f3e81b321ee438eab5d990987a035b2 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2025-02-18T05:18:20Z |
| publishDate | 2019-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-3f3e81b321ee438eab5d990987a035b22024-11-15T13:01:04ZengWileyCancer Medicine2045-76342019-05-01851958197510.1002/cam4.2108Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced scienceYuening Xiang0Zimu Guo1Pengfei Zhu2Jia Chen3Yongye Huang4College of Life and Health Sciences Northeastern University Shenyang ChinaCollege of Life and Health Sciences Northeastern University Shenyang ChinaCollege of Life and Health Sciences Northeastern University Shenyang ChinaCollege of Life and Health Sciences Northeastern University Shenyang ChinaCollege of Life and Health Sciences Northeastern University Shenyang ChinaAbstract Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activity of TCM, especially that of the Chinese herbal medicine‐derived phytochemicals curcumin, resveratrol, and berberine. Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. In addition, the impact of TCM treatment on DNA methylation, histone modification, and the regulation of noncoding RNAs is discussed. Furthermore, we have highlighted studies of TCM therapy that modulate the tumor microenvironment and eliminate cancer stem cells. The information compiled in this review will serve as a solid foundation to formulate hypotheses for future studies on TCM‐based cancer therapy.https://doi.org/10.1002/cam4.2108cancer stem cellsepigeneticsmicroenvironmentoncogenetraditional Chinese medicine |
| spellingShingle | Yuening Xiang Zimu Guo Pengfei Zhu Jia Chen Yongye Huang Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science Cancer Medicine cancer stem cells epigenetics microenvironment oncogene traditional Chinese medicine |
| title | Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science |
| title_full | Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science |
| title_fullStr | Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science |
| title_full_unstemmed | Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science |
| title_short | Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science |
| title_sort | traditional chinese medicine as a cancer treatment modern perspectives of ancient but advanced science |
| topic | cancer stem cells epigenetics microenvironment oncogene traditional Chinese medicine |
| url | https://doi.org/10.1002/cam4.2108 |
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