Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation
Mesoporous Bioactive Glasses (MBGs) are biomaterials widely used in tissue engineering, particularly for hard tissue regeneration. One of the most frequent postoperative complications following a biomaterial surgical implant is a bacterial infection, which usually requires treatment by the systemic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/3/129 |
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| author | Francesca Fraulini Stefano Raimondi Francesco Candeliere Raffaella Ranieri Alfonso Zambon Gigliola Lusvardi |
| author_facet | Francesca Fraulini Stefano Raimondi Francesco Candeliere Raffaella Ranieri Alfonso Zambon Gigliola Lusvardi |
| author_sort | Francesca Fraulini |
| collection | DOAJ |
| description | Mesoporous Bioactive Glasses (MBGs) are biomaterials widely used in tissue engineering, particularly for hard tissue regeneration. One of the most frequent postoperative complications following a biomaterial surgical implant is a bacterial infection, which usually requires treatment by the systemic administration of drugs (e.g., antibiotics). In order to develop biomaterials with antibiotic properties, we investigated cerium-doped MBGs (Ce-MBGs) as in situ-controlled drug delivery systems (DDSs) of gentamicin (Gen), a wide spectrum antibiotic commonly employed against bacteria responsible of postoperative infections. Here we report the optimization of Gen loading on MBGs and the evaluation of the antibacterial properties and of retention of bioactivity and antioxidant properties of the resulting materials. The Gen loading (up to 7%) was found to be independent from cerium content, and the optimized Gen-loaded Ce-MBGs retain significant bioactivity and antioxidant properties. The antibacterial efficacy was verified up to 10 days of controlled release. These properties make Gen-loaded Ce-MBGs interesting candidates for simultaneous hard tissue regeneration and in situ antibiotic release. |
| first_indexed | 2024-03-11T06:21:00Z |
| format | Article |
| id | doaj.art-3f4060ddd29b45b2b184a01142bddd32 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T06:21:00Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-3f4060ddd29b45b2b184a01142bddd322023-11-17T11:54:00ZengMDPI AGJournal of Functional Biomaterials2079-49832023-02-0114312910.3390/jfb14030129Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro EvaluationFrancesca Fraulini0Stefano Raimondi1Francesco Candeliere2Raffaella Ranieri3Alfonso Zambon4Gigliola Lusvardi5Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Chemical and Geological Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyMesoporous Bioactive Glasses (MBGs) are biomaterials widely used in tissue engineering, particularly for hard tissue regeneration. One of the most frequent postoperative complications following a biomaterial surgical implant is a bacterial infection, which usually requires treatment by the systemic administration of drugs (e.g., antibiotics). In order to develop biomaterials with antibiotic properties, we investigated cerium-doped MBGs (Ce-MBGs) as in situ-controlled drug delivery systems (DDSs) of gentamicin (Gen), a wide spectrum antibiotic commonly employed against bacteria responsible of postoperative infections. Here we report the optimization of Gen loading on MBGs and the evaluation of the antibacterial properties and of retention of bioactivity and antioxidant properties of the resulting materials. The Gen loading (up to 7%) was found to be independent from cerium content, and the optimized Gen-loaded Ce-MBGs retain significant bioactivity and antioxidant properties. The antibacterial efficacy was verified up to 10 days of controlled release. These properties make Gen-loaded Ce-MBGs interesting candidates for simultaneous hard tissue regeneration and in situ antibiotic release.https://www.mdpi.com/2079-4983/14/3/129bioactive glassesceriumbioactivityantibacterial activity |
| spellingShingle | Francesca Fraulini Stefano Raimondi Francesco Candeliere Raffaella Ranieri Alfonso Zambon Gigliola Lusvardi Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation Journal of Functional Biomaterials bioactive glasses cerium bioactivity antibacterial activity |
| title | Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation |
| title_full | Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation |
| title_fullStr | Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation |
| title_full_unstemmed | Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation |
| title_short | Ce-MBGs Loaded with Gentamicin: Characterization and In Vitro Evaluation |
| title_sort | ce mbgs loaded with gentamicin characterization and in vitro evaluation |
| topic | bioactive glasses cerium bioactivity antibacterial activity |
| url | https://www.mdpi.com/2079-4983/14/3/129 |
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