Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections
Relationship between presepsin values and shortterm status of patients with infections, as well as a correlation of presepsin levels and other markers of systemic inflammatory response were analyzed in this prospective observational study. The study included patients with different types of nosocomi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2015-08-01
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| Series: | Клиническая микробиология и антимикробная химиотерапия |
| Subjects: | |
| Online Access: | https://cmac-journal.ru/publication/2015/3/cmac-2015-t17-n3-p235/cmac-2015-t17-n3-p235.pdf |
| _version_ | 1818938027537334272 |
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| author | Zagorodnikova K.A. Gaykovaya L.B. Burbello A.T. Kostitsyna M.A. Pokladova M.V. Ermakov A.I. Komok M.V. |
| author_facet | Zagorodnikova K.A. Gaykovaya L.B. Burbello A.T. Kostitsyna M.A. Pokladova M.V. Ermakov A.I. Komok M.V. |
| author_sort | Zagorodnikova K.A. |
| collection | DOAJ |
| description | Relationship between presepsin values and shortterm status of patients with infections, as well as a correlation of presepsin levels and other markers of systemic inflammatory response were analyzed in this prospective observational study. The study included patients with different types of nosocomial infections receiving empiric antimicrobial therapy. Analysis of laboratory values was performed at different time-points at the discretion of treating physician. Laboratory values were the following: presepsin (using «Pathfast® presepsin» assay), procalcitonin, C-reactive protein, total white blood cells, neutrophils, and band forms of neutrophils. Changes in patient’s clinical status in the first 3 days after analysis and patient deaths from infections in the first week after analysis were evaluated retrospectively. Data were analyzed as nonparametric values; correlation analysis was performed using Spearman test; mean values were compared using the Mann-Whitney test. A total of 71 measurements from 38 patients were analyzed. Presepsin levels (1365 pg/ ml) were significantly increased in patients with clinical worsening in the first 3 days compared to 440 pg/ml in patients without worsening (p<0.0001). Corresponding procalcitonin levels were 2.67 ng/ml and 0.43 ng/ml (p<0.001). Presepsin and procalcitonin values had significant moderate correlation (Spearman r = 0.43, p=0.002). Presepsin levels promptly predicted short-term changes in status of patients with nosocomial infections in the majority cases. |
| first_indexed | 2024-12-20T06:01:19Z |
| format | Article |
| id | doaj.art-3f4060df63af4134b7a614e7463af36c |
| institution | Directory Open Access Journal |
| issn | 1684-4386 2686-9586 |
| language | Russian |
| last_indexed | 2024-12-20T06:01:19Z |
| publishDate | 2015-08-01 |
| publisher | Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy |
| record_format | Article |
| series | Клиническая микробиология и антимикробная химиотерапия |
| spelling | doaj.art-3f4060df63af4134b7a614e7463af36c2022-12-21T19:50:54ZrusInterregional Association for Clinical Microbiology and Antimicrobial ChemotherapyКлиническая микробиология и антимикробная химиотерапия1684-43862686-95862015-08-01173235240cmac-2015-t17-n3-p235Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial InfectionsZagorodnikova K.A.0Gaykovaya L.B.1Burbello A.T.2Kostitsyna M.A.3Pokladova M.V.4Ermakov A.I.5Komok M.V.6North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaNorth-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, RussiaRelationship between presepsin values and shortterm status of patients with infections, as well as a correlation of presepsin levels and other markers of systemic inflammatory response were analyzed in this prospective observational study. The study included patients with different types of nosocomial infections receiving empiric antimicrobial therapy. Analysis of laboratory values was performed at different time-points at the discretion of treating physician. Laboratory values were the following: presepsin (using «Pathfast® presepsin» assay), procalcitonin, C-reactive protein, total white blood cells, neutrophils, and band forms of neutrophils. Changes in patient’s clinical status in the first 3 days after analysis and patient deaths from infections in the first week after analysis were evaluated retrospectively. Data were analyzed as nonparametric values; correlation analysis was performed using Spearman test; mean values were compared using the Mann-Whitney test. A total of 71 measurements from 38 patients were analyzed. Presepsin levels (1365 pg/ ml) were significantly increased in patients with clinical worsening in the first 3 days compared to 440 pg/ml in patients without worsening (p<0.0001). Corresponding procalcitonin levels were 2.67 ng/ml and 0.43 ng/ml (p<0.001). Presepsin and procalcitonin values had significant moderate correlation (Spearman r = 0.43, p=0.002). Presepsin levels promptly predicted short-term changes in status of patients with nosocomial infections in the majority cases.https://cmac-journal.ru/publication/2015/3/cmac-2015-t17-n3-p235/cmac-2015-t17-n3-p235.pdfpresepsinprocalcitoninnosocomial infectionprognosisinflammatory markers |
| spellingShingle | Zagorodnikova K.A. Gaykovaya L.B. Burbello A.T. Kostitsyna M.A. Pokladova M.V. Ermakov A.I. Komok M.V. Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections Клиническая микробиология и антимикробная химиотерапия presepsin procalcitonin nosocomial infection prognosis inflammatory markers |
| title | Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections |
| title_full | Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections |
| title_fullStr | Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections |
| title_full_unstemmed | Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections |
| title_short | Role of Presepsin in Predicting ShortTerm Patient’s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections |
| title_sort | role of presepsin in predicting shortterm patient s status changes and preventing excessive antimicrobial therapy in patients with nosocomial infections |
| topic | presepsin procalcitonin nosocomial infection prognosis inflammatory markers |
| url | https://cmac-journal.ru/publication/2015/3/cmac-2015-t17-n3-p235/cmac-2015-t17-n3-p235.pdf |
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