Recent advances in the diagnosis of immune mediated demyelinating neuropathies
Inflammatory neuropathies are a group of acquired neuropathies which could be due to autoimmune, infectious, paraneoplastic, or paraproteinemic etiology. The etiological diagnosis of inflammatory neuropathy is not simple, and often requires combination of clinical, electrophysiological, and histopat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=5;spage=310;epage=317;aulast=Rao |
| _version_ | 1811317680751247360 |
|---|---|
| author | Shilpa Rao Madhu Nagappa Anita Mahadevan |
| author_facet | Shilpa Rao Madhu Nagappa Anita Mahadevan |
| author_sort | Shilpa Rao |
| collection | DOAJ |
| description | Inflammatory neuropathies are a group of acquired neuropathies which could be due to autoimmune, infectious, paraneoplastic, or paraproteinemic etiology. The etiological diagnosis of inflammatory neuropathy is not simple, and often requires combination of clinical, electrophysiological, and histopathological findings to arrive at a precise diagnosis which is important for management of the disorder. Whereas there are comprehensive and sensitive panel of serological tests available for diagnosis of the infectious, paraneoplastic, paraproteinemic neuropathies, the diagnosis of immune-mediated demyelinating neuropathies remain a considerable challenge as there is both clinical and pathological overlap. Newer non-invasive methodologies such as high-resolution ultrasound, magnetic resonance imaging (MRI), and importantly, serological testing for antibodies are emerging, and it is essential for the practicing pathologist to be up-to-date with emerging modalities. In this review, we focus on the approach to diagnosis of immune-mediated demyelinating neuropathies. |
| first_indexed | 2024-04-13T12:12:32Z |
| format | Article |
| id | doaj.art-3f44037f45b7475e91b09adcf8ef895a |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-04-13T12:12:32Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-3f44037f45b7475e91b09adcf8ef895a2022-12-22T02:47:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292022-01-0165531031710.4103/ijpm.ijpm_50_22Recent advances in the diagnosis of immune mediated demyelinating neuropathiesShilpa RaoMadhu NagappaAnita MahadevanInflammatory neuropathies are a group of acquired neuropathies which could be due to autoimmune, infectious, paraneoplastic, or paraproteinemic etiology. The etiological diagnosis of inflammatory neuropathy is not simple, and often requires combination of clinical, electrophysiological, and histopathological findings to arrive at a precise diagnosis which is important for management of the disorder. Whereas there are comprehensive and sensitive panel of serological tests available for diagnosis of the infectious, paraneoplastic, paraproteinemic neuropathies, the diagnosis of immune-mediated demyelinating neuropathies remain a considerable challenge as there is both clinical and pathological overlap. Newer non-invasive methodologies such as high-resolution ultrasound, magnetic resonance imaging (MRI), and importantly, serological testing for antibodies are emerging, and it is essential for the practicing pathologist to be up-to-date with emerging modalities. In this review, we focus on the approach to diagnosis of immune-mediated demyelinating neuropathies.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=5;spage=310;epage=317;aulast=Raodemyelinatingdiagnosisinflammatorynerve biopsyneuropathiesserology |
| spellingShingle | Shilpa Rao Madhu Nagappa Anita Mahadevan Recent advances in the diagnosis of immune mediated demyelinating neuropathies Indian Journal of Pathology and Microbiology demyelinating diagnosis inflammatory nerve biopsy neuropathies serology |
| title | Recent advances in the diagnosis of immune mediated demyelinating neuropathies |
| title_full | Recent advances in the diagnosis of immune mediated demyelinating neuropathies |
| title_fullStr | Recent advances in the diagnosis of immune mediated demyelinating neuropathies |
| title_full_unstemmed | Recent advances in the diagnosis of immune mediated demyelinating neuropathies |
| title_short | Recent advances in the diagnosis of immune mediated demyelinating neuropathies |
| title_sort | recent advances in the diagnosis of immune mediated demyelinating neuropathies |
| topic | demyelinating diagnosis inflammatory nerve biopsy neuropathies serology |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=5;spage=310;epage=317;aulast=Rao |
| work_keys_str_mv | AT shilparao recentadvancesinthediagnosisofimmunemediateddemyelinatingneuropathies AT madhunagappa recentadvancesinthediagnosisofimmunemediateddemyelinatingneuropathies AT anitamahadevan recentadvancesinthediagnosisofimmunemediateddemyelinatingneuropathies |