SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells

Summary: Cholesterol is a structural component of cell membranes. How rapidly growing tumor cells maintain membrane cholesterol homeostasis is poorly understood. Here, we found that glioblastoma (GBM), the most lethal brain tumor, maintains normal levels of membrane cholesterol but with an abundant...

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Bibliographic Details
Main Authors: Feng Geng, Yaogang Zhong, Huali Su, Etienne Lefai, Shino Magaki, Timothy F. Cloughesy, William H. Yong, Arnab Chakravarti, Deliang Guo
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Metabolism
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300801X

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