Microarray analysis of genes differentially expressed in the liver of lean and fat chickens
Excessive accumulation of lipids in the adipose tissue is one of the main problems faced by the broiler industry nowadays. In chicken, lipogenesis occurs essentially in the liver, in which much of the triglycerides that accumulate in avian adipose tissue are synthesized. In order to better understan...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-01-01
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| Series: | Animal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1751731109991388 |
| _version_ | 1818448285482876928 |
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| author | H.B. Wang Q.G. Wang X.Y. Zhang X.F. Gu N. Wang S.B. Wu H. Li |
| author_facet | H.B. Wang Q.G. Wang X.Y. Zhang X.F. Gu N. Wang S.B. Wu H. Li |
| author_sort | H.B. Wang |
| collection | DOAJ |
| description | Excessive accumulation of lipids in the adipose tissue is one of the main problems faced by the broiler industry nowadays. In chicken, lipogenesis occurs essentially in the liver, in which much of the triglycerides that accumulate in avian adipose tissue are synthesized. In order to better understand the gene expression and its regulation in chicken liver, the gene expression profiles of liver at developmental stages of chicken (1 week, 4 weeks and 7 weeks of age) were investigated and differentially expressed genes between lean and fat chicken lines divergently selected for abdominal fat content for eight generations were screened. Our data indicated that 4 weeks of age was a very important stage on chicken liver lipogenesis compared to 1 week and 7 weeks of age, and the glycometabolism in chicken liver could be related to lipid metabolism and the difference of glycometabolism could be another potential reason for the fat and lean phenotype occurrence besides the difference of lipogenesis in chicken liver. Our result have established groundwork for further study of the basic genetic control of chicken obesity and will benefit chicken research communities as well as researches that use chicken as a model organism for developmental biology and human therapeutics. |
| first_indexed | 2024-12-14T20:17:05Z |
| format | Article |
| id | doaj.art-3f48c54427f44394998c71fa803878ed |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-12-14T20:17:05Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier |
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| series | Animal |
| spelling | doaj.art-3f48c54427f44394998c71fa803878ed2022-12-21T22:48:49ZengElsevierAnimal1751-73112010-01-0144513522Microarray analysis of genes differentially expressed in the liver of lean and fat chickensH.B. Wang0Q.G. Wang1X.Y. Zhang2X.F. Gu3N. Wang4S.B. Wu5H. Li6College of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. ChinaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. ChinaMinistry of Education Key Laboratory of Bioinformatics, School of Biomedicine, Tsinghua University, Beijing, 100084, P.R. ChinaHarbin Gene-Tech Biochip Development Inc., LTD, Harbin, Heilongjiang 150090, ChinaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. ChinaSchool of Environmental and Rural Science and The Institute of Genomics and Bioinformatics, The University of New England, Armidale, AustraliaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. ChinaExcessive accumulation of lipids in the adipose tissue is one of the main problems faced by the broiler industry nowadays. In chicken, lipogenesis occurs essentially in the liver, in which much of the triglycerides that accumulate in avian adipose tissue are synthesized. In order to better understand the gene expression and its regulation in chicken liver, the gene expression profiles of liver at developmental stages of chicken (1 week, 4 weeks and 7 weeks of age) were investigated and differentially expressed genes between lean and fat chicken lines divergently selected for abdominal fat content for eight generations were screened. Our data indicated that 4 weeks of age was a very important stage on chicken liver lipogenesis compared to 1 week and 7 weeks of age, and the glycometabolism in chicken liver could be related to lipid metabolism and the difference of glycometabolism could be another potential reason for the fat and lean phenotype occurrence besides the difference of lipogenesis in chicken liver. Our result have established groundwork for further study of the basic genetic control of chicken obesity and will benefit chicken research communities as well as researches that use chicken as a model organism for developmental biology and human therapeutics.http://www.sciencedirect.com/science/article/pii/S1751731109991388chickenlivergene expression profilelipid metabolism |
| spellingShingle | H.B. Wang Q.G. Wang X.Y. Zhang X.F. Gu N. Wang S.B. Wu H. Li Microarray analysis of genes differentially expressed in the liver of lean and fat chickens Animal chicken liver gene expression profile lipid metabolism |
| title | Microarray analysis of genes differentially expressed in the liver of lean and fat chickens |
| title_full | Microarray analysis of genes differentially expressed in the liver of lean and fat chickens |
| title_fullStr | Microarray analysis of genes differentially expressed in the liver of lean and fat chickens |
| title_full_unstemmed | Microarray analysis of genes differentially expressed in the liver of lean and fat chickens |
| title_short | Microarray analysis of genes differentially expressed in the liver of lean and fat chickens |
| title_sort | microarray analysis of genes differentially expressed in the liver of lean and fat chickens |
| topic | chicken liver gene expression profile lipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S1751731109991388 |
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