Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive Function
BackgroundSleep apnea leads to cognitive impairment in older patients, but its association with neurodegeneration remains controversial, and most studies do not distinguish between the more common obstructive form (OSAS) and the rarer central form (CSAS).ObjectiveThe purpose of this study was to ass...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00361/full |
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| author | Jadwiga Attier-Zmudka Jadwiga Attier-Zmudka Jean-Marie Sérot Jeremy Valluy Mo Saffarini Youcef Douadi Krzysztof Piotr Malinowski Olivier Balédent Olivier Balédent |
| author_facet | Jadwiga Attier-Zmudka Jadwiga Attier-Zmudka Jean-Marie Sérot Jeremy Valluy Mo Saffarini Youcef Douadi Krzysztof Piotr Malinowski Olivier Balédent Olivier Balédent |
| author_sort | Jadwiga Attier-Zmudka |
| collection | DOAJ |
| description | BackgroundSleep apnea leads to cognitive impairment in older patients, but its association with neurodegeneration remains controversial, and most studies do not distinguish between the more common obstructive form (OSAS) and the rarer central form (CSAS).ObjectiveThe purpose of this study was to assess the prevalence of the different forms of sleep apnea in a cohort of cognitively impaired elderly patients (>70 years) and to investigate their associations with cognitive deficit, weighted against known risk factors for neurodegeneration.MethodsOvernight polygraphy was performed for 76 consecutive patients admitted to our geriatric unit. Their cognitive function was assessed using the Mini Mental-State Exam (MMSE), Mattis Dementia Rating Scale (MDRS) and Stroop test. Multivariable analyses were performed to determine associations between cognitive function and independent variables describing demographics, sleep apnea measures, and cardiovascular risk factors.ResultsThe cohort comprised 58 women and 18 men aged a mean of 84 years (range, 73–96). Sleep apnea syndrome (SAS) was diagnosed in 48 patients (63%), of which 31 (41%) with OSAS and 17 (22%) with CSAS. Multivariable regression analysis revealed that MDRS was lower in patients with OSAS (β = −10.03, p = 0.018), that Stroop Colors and Words delays increased with AHI (β = 0.17, p = 0.030 and β = 0.31, p = 0.047) and that that Stroop Interference delay was higher in patients with CSAS (β = 24.45, p = 0.002).ConclusionSleep apnea is thus highly prevalent in elderly patients with cognitive impairment. OSAS was associated with lower general cognitive function, while CSAS was only associated with increased Stroop Interference delays. Elderly patients with cognitive deficit could benefit from sleep apnea screening and treatment. |
| first_indexed | 2024-12-19T20:04:38Z |
| format | Article |
| id | doaj.art-3f4a3c99c085422fb57fea251d185d91 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-19T20:04:38Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-3f4a3c99c085422fb57fea251d185d912022-12-21T20:07:32ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-01-011110.3389/fnagi.2019.00361438926Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive FunctionJadwiga Attier-Zmudka0Jadwiga Attier-Zmudka1Jean-Marie Sérot2Jeremy Valluy3Mo Saffarini4Youcef Douadi5Krzysztof Piotr Malinowski6Olivier Balédent7Olivier Balédent8Department of Gerontology, Saint-Quentin Hospital, Saint-Quentin, FranceCHIMERE, EA 7516 Head & Neck Research Group, University of Picardy Jules Verne, Amiens, FranceDepartment of Gerontology, Saint-Quentin Hospital, Saint-Quentin, FranceReSurg SA, Nyon, SwitzerlandReSurg SA, Nyon, SwitzerlandDepartment of Pulmonology, Saint-Quentin Hospital, Saint-Quentin, FranceInstitute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, PolandCHIMERE, EA 7516 Head & Neck Research Group, University of Picardy Jules Verne, Amiens, FranceBioFlowImage, Image Processing Unit, University Hospital of Amiens, Amiens, FranceBackgroundSleep apnea leads to cognitive impairment in older patients, but its association with neurodegeneration remains controversial, and most studies do not distinguish between the more common obstructive form (OSAS) and the rarer central form (CSAS).ObjectiveThe purpose of this study was to assess the prevalence of the different forms of sleep apnea in a cohort of cognitively impaired elderly patients (>70 years) and to investigate their associations with cognitive deficit, weighted against known risk factors for neurodegeneration.MethodsOvernight polygraphy was performed for 76 consecutive patients admitted to our geriatric unit. Their cognitive function was assessed using the Mini Mental-State Exam (MMSE), Mattis Dementia Rating Scale (MDRS) and Stroop test. Multivariable analyses were performed to determine associations between cognitive function and independent variables describing demographics, sleep apnea measures, and cardiovascular risk factors.ResultsThe cohort comprised 58 women and 18 men aged a mean of 84 years (range, 73–96). Sleep apnea syndrome (SAS) was diagnosed in 48 patients (63%), of which 31 (41%) with OSAS and 17 (22%) with CSAS. Multivariable regression analysis revealed that MDRS was lower in patients with OSAS (β = −10.03, p = 0.018), that Stroop Colors and Words delays increased with AHI (β = 0.17, p = 0.030 and β = 0.31, p = 0.047) and that that Stroop Interference delay was higher in patients with CSAS (β = 24.45, p = 0.002).ConclusionSleep apnea is thus highly prevalent in elderly patients with cognitive impairment. OSAS was associated with lower general cognitive function, while CSAS was only associated with increased Stroop Interference delays. Elderly patients with cognitive deficit could benefit from sleep apnea screening and treatment.https://www.frontiersin.org/article/10.3389/fnagi.2019.00361/fullsleep apneacognitive deficitelderly populationOSASCSAS |
| spellingShingle | Jadwiga Attier-Zmudka Jadwiga Attier-Zmudka Jean-Marie Sérot Jeremy Valluy Mo Saffarini Youcef Douadi Krzysztof Piotr Malinowski Olivier Balédent Olivier Balédent Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive Function Frontiers in Aging Neuroscience sleep apnea cognitive deficit elderly population OSAS CSAS |
| title | Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive Function |
| title_full | Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive Function |
| title_fullStr | Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive Function |
| title_full_unstemmed | Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive Function |
| title_short | Sleep Apnea Syndrome in an Elderly Population Admitted to a Geriatric Unit: Prevalence and Effect on Cognitive Function |
| title_sort | sleep apnea syndrome in an elderly population admitted to a geriatric unit prevalence and effect on cognitive function |
| topic | sleep apnea cognitive deficit elderly population OSAS CSAS |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00361/full |
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