Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort
Objectives: This study aimed to evaluate the joint effects of multiple air pollutants including PM2.5, PM10, NO2, and NOx with dementia and examined the modifying effects of genetic susceptibility.Methods: This study included 220,963 UK Biobank participants without dementia at baseline. Weighted air...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | International Journal of Public Health |
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| Online Access: | https://www.ssph-journal.org/articles/10.3389/ijph.2024.1606868/full |
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| author | Shuo Zhang Hongyan Cao Keying Chen Tongyu Gao Huashuo Zhao Chu Zheng Chu Zheng Chu Zheng Chu Zheng Chu Zheng Chu Zheng Ting Wang Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ke Wang Ke Wang Ke Wang Ke Wang Ke Wang Ke Wang |
| author_facet | Shuo Zhang Hongyan Cao Keying Chen Tongyu Gao Huashuo Zhao Chu Zheng Chu Zheng Chu Zheng Chu Zheng Chu Zheng Chu Zheng Ting Wang Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ke Wang Ke Wang Ke Wang Ke Wang Ke Wang Ke Wang |
| author_sort | Shuo Zhang |
| collection | DOAJ |
| description | Objectives: This study aimed to evaluate the joint effects of multiple air pollutants including PM2.5, PM10, NO2, and NOx with dementia and examined the modifying effects of genetic susceptibility.Methods: This study included 220,963 UK Biobank participants without dementia at baseline. Weighted air pollution score reflecting the joint exposure to multiple air pollutants were constructed by cross-validation analyses, and inverse-variance weighted meta-analyses were performed to create a pooled effect. The modifying effect of genetic susceptibility on air pollution score was assessed by genetic risk score and APOE ε4 genotype.Results: The HR (95% CI) of dementia for per interquartile range increase of air pollution score was 1.13 (1.07∼1.18). Compared with the lowest quartile (Q1) of air pollution score, the HR (95% CI) of Q4 was 1.26 (1.13∼1.40) (Ptrend = 2.17 × 10−5). Participants with high air pollution score and high genetic susceptibility had higher risk of dementia compared to those with low air pollution score and low genetic susceptibility.Conclusion: Our study provides evidence that joint exposure to multiple air pollutants substantially increases the risk of dementia, especially among individuals with high genetic susceptibility. |
| first_indexed | 2024-03-08T00:50:48Z |
| format | Article |
| id | doaj.art-3f4b280ab89d4d8eb62c9672f62f2552 |
| institution | Directory Open Access Journal |
| issn | 1661-8564 |
| language | English |
| last_indexed | 2024-03-08T00:50:48Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | International Journal of Public Health |
| spelling | doaj.art-3f4b280ab89d4d8eb62c9672f62f25522024-02-15T04:11:04ZengFrontiers Media S.A.International Journal of Public Health1661-85642024-02-016910.3389/ijph.2024.16068681606868Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank CohortShuo Zhang0Hongyan Cao1Keying Chen2Tongyu Gao3Huashuo Zhao4Chu Zheng5Chu Zheng6Chu Zheng7Chu Zheng8Chu Zheng9Chu Zheng10Ting Wang11Ping Zeng12Ping Zeng13Ping Zeng14Ping Zeng15Ping Zeng16Ping Zeng17Ke Wang18Ke Wang19Ke Wang20Ke Wang21Ke Wang22Ke Wang23Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDivision of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaCenter for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Environment and Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaXuzhou Engineering Research Innovation Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaCenter for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Environment and Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaXuzhou Engineering Research Innovation Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaCenter for Medical Statistics and Data Analysis, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Human Genetics and Environmental Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaKey Laboratory of Environment and Health, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaXuzhou Engineering Research Innovation Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaObjectives: This study aimed to evaluate the joint effects of multiple air pollutants including PM2.5, PM10, NO2, and NOx with dementia and examined the modifying effects of genetic susceptibility.Methods: This study included 220,963 UK Biobank participants without dementia at baseline. Weighted air pollution score reflecting the joint exposure to multiple air pollutants were constructed by cross-validation analyses, and inverse-variance weighted meta-analyses were performed to create a pooled effect. The modifying effect of genetic susceptibility on air pollution score was assessed by genetic risk score and APOE ε4 genotype.Results: The HR (95% CI) of dementia for per interquartile range increase of air pollution score was 1.13 (1.07∼1.18). Compared with the lowest quartile (Q1) of air pollution score, the HR (95% CI) of Q4 was 1.26 (1.13∼1.40) (Ptrend = 2.17 × 10−5). Participants with high air pollution score and high genetic susceptibility had higher risk of dementia compared to those with low air pollution score and low genetic susceptibility.Conclusion: Our study provides evidence that joint exposure to multiple air pollutants substantially increases the risk of dementia, especially among individuals with high genetic susceptibility.https://www.ssph-journal.org/articles/10.3389/ijph.2024.1606868/fullmultiple air pollutantslong-term exposuredementiajoint associationprospective cohort study |
| spellingShingle | Shuo Zhang Hongyan Cao Keying Chen Tongyu Gao Huashuo Zhao Chu Zheng Chu Zheng Chu Zheng Chu Zheng Chu Zheng Chu Zheng Ting Wang Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ping Zeng Ke Wang Ke Wang Ke Wang Ke Wang Ke Wang Ke Wang Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort International Journal of Public Health multiple air pollutants long-term exposure dementia joint association prospective cohort study |
| title | Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort |
| title_full | Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort |
| title_fullStr | Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort |
| title_full_unstemmed | Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort |
| title_short | Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort |
| title_sort | joint exposure to multiple air pollutants genetic susceptibility and incident dementia a prospective analysis in the uk biobank cohort |
| topic | multiple air pollutants long-term exposure dementia joint association prospective cohort study |
| url | https://www.ssph-journal.org/articles/10.3389/ijph.2024.1606868/full |
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