Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma

Targeting PIN1 as a Therapeutic Approach for Hepatocellular Carcinoma

PIN1 is a peptidyl-prolyl cis/trans isomerase that specifically binds and catalyzes the cis/trans isomerization of the phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif of its interacting proteins. Through this phosphorylation-dependent prolyl isomerization, PIN1 is...

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Bibliographic Details
Main Authors: Chi-Wai Cheng, Eric Tse
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PIN1
phosphorylation
hepatocellular carcinoma
inhibitor
hepatocarcinogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00369/full

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