MicroRNAs, DNA Damage Response, and Cancer Treatment
As a result of various stresses, lesions caused by DNA-damaging agents occur constantly in each cell of the human body. Generally, DNA damage is recognized and repaired by the DNA damage response (DDR) machinery, and the cells survive. When repair fails, the genomic integrity of the cell is disrupte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/17/12/2087 |
| _version_ | 1811320361130655744 |
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| author | Mingyang He Weiwei Zhou Chuang Li Mingxiong Guo |
| author_facet | Mingyang He Weiwei Zhou Chuang Li Mingxiong Guo |
| author_sort | Mingyang He |
| collection | DOAJ |
| description | As a result of various stresses, lesions caused by DNA-damaging agents occur constantly in each cell of the human body. Generally, DNA damage is recognized and repaired by the DNA damage response (DDR) machinery, and the cells survive. When repair fails, the genomic integrity of the cell is disrupted—a hallmark of cancer. In addition, the DDR plays a dual role in cancer development and therapy. Cancer radiotherapy and chemotherapy are designed to eliminate cancer cells by inducing DNA damage, which in turn can promote tumorigenesis. Over the past two decades, an increasing number of microRNAs (miRNAs), small noncoding RNAs, have been identified as participating in the processes regulating tumorigenesis and responses to cancer treatment with radiation therapy or genotoxic chemotherapies, by modulating the DDR. The purpose of this review is to summarize the recent findings on how miRNAs regulate the DDR and discuss the therapeutic functions of miRNAs in cancer in the context of DDR regulation. |
| first_indexed | 2024-04-13T12:58:22Z |
| format | Article |
| id | doaj.art-3f4cfa8bac714f73bd845617e4f9fbad |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T12:58:22Z |
| publishDate | 2016-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3f4cfa8bac714f73bd845617e4f9fbad2022-12-22T02:45:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-12-011712208710.3390/ijms17122087ijms17122087MicroRNAs, DNA Damage Response, and Cancer TreatmentMingyang He0Weiwei Zhou1Chuang Li2Mingxiong Guo3Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaAs a result of various stresses, lesions caused by DNA-damaging agents occur constantly in each cell of the human body. Generally, DNA damage is recognized and repaired by the DNA damage response (DDR) machinery, and the cells survive. When repair fails, the genomic integrity of the cell is disrupted—a hallmark of cancer. In addition, the DDR plays a dual role in cancer development and therapy. Cancer radiotherapy and chemotherapy are designed to eliminate cancer cells by inducing DNA damage, which in turn can promote tumorigenesis. Over the past two decades, an increasing number of microRNAs (miRNAs), small noncoding RNAs, have been identified as participating in the processes regulating tumorigenesis and responses to cancer treatment with radiation therapy or genotoxic chemotherapies, by modulating the DDR. The purpose of this review is to summarize the recent findings on how miRNAs regulate the DDR and discuss the therapeutic functions of miRNAs in cancer in the context of DDR regulation.http://www.mdpi.com/1422-0067/17/12/2087microRNAsDNA damage responseDNA repairradiotherapychemotherapy |
| spellingShingle | Mingyang He Weiwei Zhou Chuang Li Mingxiong Guo MicroRNAs, DNA Damage Response, and Cancer Treatment International Journal of Molecular Sciences microRNAs DNA damage response DNA repair radiotherapy chemotherapy |
| title | MicroRNAs, DNA Damage Response, and Cancer Treatment |
| title_full | MicroRNAs, DNA Damage Response, and Cancer Treatment |
| title_fullStr | MicroRNAs, DNA Damage Response, and Cancer Treatment |
| title_full_unstemmed | MicroRNAs, DNA Damage Response, and Cancer Treatment |
| title_short | MicroRNAs, DNA Damage Response, and Cancer Treatment |
| title_sort | micrornas dna damage response and cancer treatment |
| topic | microRNAs DNA damage response DNA repair radiotherapy chemotherapy |
| url | http://www.mdpi.com/1422-0067/17/12/2087 |
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