Accumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effects
Heavy metals could exert a strong cardiotoxic effect, since cardiomyocytes are vulnerable cells in general, very sensitive to heavy metals-induced toxicity. The correlation between exposure to heavy metals and their contribution to the pathophysiology of diverse cardiovascular disorders, such as cor...
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| Format: | Article |
| Language: | English |
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University of Belgrade, Medical Faculty
2023-01-01
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| Series: | Medicinski Podmladak |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272305021Q.pdf |
| _version_ | 1797223713661255680 |
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| author | Ćirović Ana Tasić Nebojša |
| author_facet | Ćirović Ana Tasić Nebojša |
| author_sort | Ćirović Ana |
| collection | DOAJ |
| description | Heavy metals could exert a strong cardiotoxic effect, since cardiomyocytes are vulnerable cells in general, very sensitive to heavy metals-induced toxicity. The correlation between exposure to heavy metals and their contribution to the pathophysiology of diverse cardiovascular disorders, such as coronary artery disease (CAD) and cardiomyopathies (CMPs), has gained recognition primarily through clinical investigations wherein metal(loid) levels were quantified in the blood or urine of individuals afflicted with aforementioned disorders. However, a crucial perspective is absent due to lack of studies that investigate the accumulation of heavy metals within cardiac tissue. These studies, whether post-mortem or involving heart samples obtained during invasive procedures, are currently lacking. To achieve a comprehensive understanding of the potential involvement of metal(loid)s in the genesis of e.g. CMPs or CAD, these inquiries are indispensable. Furthermore, certain comorbidities like iron deficiency may expedite the bioaccumulation of myocardial heavy metals by augmenting the density of transferrin receptor 1 (TfR1). The impact of heavy metals on the heart's contractile machinery, coupled with their potential to initiate mitochondrial apoptosis through triggered pathways, forms part of the intricate pathophysiological landscape. Central to these mechanisms is the generation of reactive oxygen species (ROS) and the peroxidation of macromolecules. This review highlights the research findings on the bioaccumulation of heavy metals within the myocardium and elucidates the molecular mechanisms through which metal(loid) s induce cardiotoxicity |
| first_indexed | 2024-04-24T13:41:36Z |
| format | Article |
| id | doaj.art-3f4fd6de6c31402a86ad0a9645f6f5aa |
| institution | Directory Open Access Journal |
| issn | 0369-1527 2466-5525 |
| language | English |
| last_indexed | 2024-04-24T13:41:36Z |
| publishDate | 2023-01-01 |
| publisher | University of Belgrade, Medical Faculty |
| record_format | Article |
| series | Medicinski Podmladak |
| spelling | doaj.art-3f4fd6de6c31402a86ad0a9645f6f5aa2024-04-04T08:28:43ZengUniversity of Belgrade, Medical FacultyMedicinski Podmladak0369-15272466-55252023-01-01745212510.5937/mp74-461640369-15272305021QAccumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effectsĆirović Ana0Tasić Nebojša1https://orcid.org/0000-0003-2465-1708Univerzitet u Beogradu, Medicinski fakultet, Institut za anatomiju "Niko Miljanić", Beograd, SerbiaUniverzitet u Beogradu, Medicinski fakultet, Beograd, SerbiaHeavy metals could exert a strong cardiotoxic effect, since cardiomyocytes are vulnerable cells in general, very sensitive to heavy metals-induced toxicity. The correlation between exposure to heavy metals and their contribution to the pathophysiology of diverse cardiovascular disorders, such as coronary artery disease (CAD) and cardiomyopathies (CMPs), has gained recognition primarily through clinical investigations wherein metal(loid) levels were quantified in the blood or urine of individuals afflicted with aforementioned disorders. However, a crucial perspective is absent due to lack of studies that investigate the accumulation of heavy metals within cardiac tissue. These studies, whether post-mortem or involving heart samples obtained during invasive procedures, are currently lacking. To achieve a comprehensive understanding of the potential involvement of metal(loid)s in the genesis of e.g. CMPs or CAD, these inquiries are indispensable. Furthermore, certain comorbidities like iron deficiency may expedite the bioaccumulation of myocardial heavy metals by augmenting the density of transferrin receptor 1 (TfR1). The impact of heavy metals on the heart's contractile machinery, coupled with their potential to initiate mitochondrial apoptosis through triggered pathways, forms part of the intricate pathophysiological landscape. Central to these mechanisms is the generation of reactive oxygen species (ROS) and the peroxidation of macromolecules. This review highlights the research findings on the bioaccumulation of heavy metals within the myocardium and elucidates the molecular mechanisms through which metal(loid) s induce cardiotoxicityhttps://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272305021Q.pdfmetals bioaccumulationmyocardiumiron deficiency |
| spellingShingle | Ćirović Ana Tasić Nebojša Accumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effects Medicinski Podmladak metals bioaccumulation myocardium iron deficiency |
| title | Accumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effects |
| title_full | Accumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effects |
| title_fullStr | Accumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effects |
| title_full_unstemmed | Accumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effects |
| title_short | Accumulation of metal(loid)s in myocardial tissue and the mechanisms underlying their cardiotoxic effects |
| title_sort | accumulation of metal loid s in myocardial tissue and the mechanisms underlying their cardiotoxic effects |
| topic | metals bioaccumulation myocardium iron deficiency |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272305021Q.pdf |
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