Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012
Purpose: Obesity is considered a risk factor for asthma exacerbation. However, limited studies have focused on the association of different levels of weight clusters with asthma. As such, we study the associations between different weight clusters with FeNO, blood eosinophils, and lung function amon...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1019123/full |
| _version_ | 1811167166443028480 |
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| author | Haoyu Zhang Haoyu Zhang Zhigang Hu Zhigang Hu Sufei Wang Jiangli Xu Jiangli Xu Sijia Li Sijia Li Xinyu Song Xinyu Song |
| author_facet | Haoyu Zhang Haoyu Zhang Zhigang Hu Zhigang Hu Sufei Wang Jiangli Xu Jiangli Xu Sijia Li Sijia Li Xinyu Song Xinyu Song |
| author_sort | Haoyu Zhang |
| collection | DOAJ |
| description | Purpose: Obesity is considered a risk factor for asthma exacerbation. However, limited studies have focused on the association of different levels of weight clusters with asthma. As such, we study the associations between different weight clusters with FeNO, blood eosinophils, and lung function among adult asthmatics.Methods: Data from 789 participants aged 20 years or older in the National Health and Nutrition Examination Survey 2007–2012 were analyzed. Body mass index (BMI) and waist circumference (WC) were used to determine the weight status. The study population was divided into five groups, including normal weight and low WC (153), normal weight and high WC (43), overweight and high WC (67), overweight and abdominal obesity (128), and general and abdominal obesity (398). A Multivariate linear regression model was used to evaluate the abovementioned associations after adjusting for potential confounding factors.Results: The adjusted models showed that general and abdominal obesity cluster (adjusted β = −0.63, 95% confidence interval (CI): −1.08, −0.17 p < 0.01), and the normal weight with high WC cluster (adjusted β = −0.96, 95% CI: −1.74, −0.19 p < 0.05) were associated with lower levels of blood eosinophils percentage than normal weight and low WC cluster. A similar tendency was shown in the levels of FeNO, but the differences were not significant (p > 0.05). Furthermore, abdominal obesity clusters were significantly associated with lower FVC, FVC% predicted, and FEV1 measures than normal weight and low WC cluster, especially those individuals with general and abdominal obesity cluster. No association was found between different weight clusters and FEV1/FVCF ratio. The two other weight clusters did not show the association with any of the lung function measures.Conclusion: General and abdominal obesity were associated with lung function impairment and a significant reduction of FeNO and blood eosinophil percentage. This study emphasized the importance of concurrent determination of BMI and WC in asthma clinical practice. |
| first_indexed | 2024-04-10T16:04:37Z |
| format | Article |
| id | doaj.art-3f50e293ba744a7383e16ff1be38a416 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T16:04:37Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj.art-3f50e293ba744a7383e16ff1be38a4162023-02-10T05:31:53ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-02-011410.3389/fphys.2023.10191231019123Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012Haoyu Zhang0Haoyu Zhang1Zhigang Hu2Zhigang Hu3Sufei Wang4Jiangli Xu5Jiangli Xu6Sijia Li7Sijia Li8Xinyu Song9Xinyu Song10Department of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, Yichang Central People’s Hospital, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, Yichang Central People’s Hospital, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, Yichang Central People’s Hospital, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, Yichang Central People’s Hospital, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang, ChinaDepartment of Respiratory and Critical Care Medicine, Yichang Central People’s Hospital, Yichang, ChinaPurpose: Obesity is considered a risk factor for asthma exacerbation. However, limited studies have focused on the association of different levels of weight clusters with asthma. As such, we study the associations between different weight clusters with FeNO, blood eosinophils, and lung function among adult asthmatics.Methods: Data from 789 participants aged 20 years or older in the National Health and Nutrition Examination Survey 2007–2012 were analyzed. Body mass index (BMI) and waist circumference (WC) were used to determine the weight status. The study population was divided into five groups, including normal weight and low WC (153), normal weight and high WC (43), overweight and high WC (67), overweight and abdominal obesity (128), and general and abdominal obesity (398). A Multivariate linear regression model was used to evaluate the abovementioned associations after adjusting for potential confounding factors.Results: The adjusted models showed that general and abdominal obesity cluster (adjusted β = −0.63, 95% confidence interval (CI): −1.08, −0.17 p < 0.01), and the normal weight with high WC cluster (adjusted β = −0.96, 95% CI: −1.74, −0.19 p < 0.05) were associated with lower levels of blood eosinophils percentage than normal weight and low WC cluster. A similar tendency was shown in the levels of FeNO, but the differences were not significant (p > 0.05). Furthermore, abdominal obesity clusters were significantly associated with lower FVC, FVC% predicted, and FEV1 measures than normal weight and low WC cluster, especially those individuals with general and abdominal obesity cluster. No association was found between different weight clusters and FEV1/FVCF ratio. The two other weight clusters did not show the association with any of the lung function measures.Conclusion: General and abdominal obesity were associated with lung function impairment and a significant reduction of FeNO and blood eosinophil percentage. This study emphasized the importance of concurrent determination of BMI and WC in asthma clinical practice.https://www.frontiersin.org/articles/10.3389/fphys.2023.1019123/fullgeneral and abdominal obesitybody mass indexwaist circumferenceasthmalung functionFeNO |
| spellingShingle | Haoyu Zhang Haoyu Zhang Zhigang Hu Zhigang Hu Sufei Wang Jiangli Xu Jiangli Xu Sijia Li Sijia Li Xinyu Song Xinyu Song Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012 Frontiers in Physiology general and abdominal obesity body mass index waist circumference asthma lung function FeNO |
| title | Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012 |
| title_full | Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012 |
| title_fullStr | Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012 |
| title_full_unstemmed | Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012 |
| title_short | Association of general and abdominal obesity with lung function, FeNO, and blood eosinophils in adult asthmatics: Findings from NHANES 2007–2012 |
| title_sort | association of general and abdominal obesity with lung function feno and blood eosinophils in adult asthmatics findings from nhanes 2007 2012 |
| topic | general and abdominal obesity body mass index waist circumference asthma lung function FeNO |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1019123/full |
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