Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene
We evaluated the effect of macrolide-resistant mutations in the <i>Mycoplasma pneumoniae</i> 23S rRNA gene on the severity of lower respiratory tract infections in immunocompetent young adults treated at the Smolensk Military Hospital between 25 October 2017, and 17 November 2021. All an...
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MDPI AG
2023-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/1/103 |
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| author | Inna Alexandrovna Edelstein Olga Vladimirovna Ivanova Oleg Igorevich Romashov Roman Sergeevich Kozlov |
| author_facet | Inna Alexandrovna Edelstein Olga Vladimirovna Ivanova Oleg Igorevich Romashov Roman Sergeevich Kozlov |
| author_sort | Inna Alexandrovna Edelstein |
| collection | DOAJ |
| description | We evaluated the effect of macrolide-resistant mutations in the <i>Mycoplasma pneumoniae</i> 23S rRNA gene on the severity of lower respiratory tract infections in immunocompetent young adults treated at the Smolensk Military Hospital between 25 October 2017, and 17 November 2021. All analyzed cases represented a non-severe infection of the lower respiratory tract: 44 case histories with community-acquired pneumonia and 20 cases with acute bronchitis. The presence of mutations in the gene 23S rRNA of <i>M. pneumoniae</i> was determined with standard Sanger sequencing. The macrolide-resistant genotype was found in 4/44 (9.1%) of the samples of the patients with pneumonia and in 3/20 (15%) of the samples of the patients with acute bronchitis. The analyzed cases with identified <i>M. pneumoniae</i> carrying a mutation in the 23S rRNA gene did not show any differences in the clinical presentation in terms of disease severity caused by <i>M. pneumoniae</i> with the wild-type (WT) phenotype. |
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| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T11:29:23Z |
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| series | Pathogens |
| spelling | doaj.art-3f513419630d46faa930e297c8d9cf4c2023-11-30T23:53:46ZengMDPI AGPathogens2076-08172023-01-0112110310.3390/pathogens12010103Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA GeneInna Alexandrovna Edelstein0Olga Vladimirovna Ivanova1Oleg Igorevich Romashov2Roman Sergeevich Kozlov3Laboratory Molecular Diagnostics, Institute of Antimicrobial Chemotherapy, Smolensk State Medical University Federal State Budgetary Educational Institution of Higher Education «Smolensk State Medical University» of the Ministry of Healthcare of the Russian Federation, Smolensk 214019, RussiaPulmonology Department, Brach No 4 of FSGI «1586 MCH» of the Ministry of Defense of the Russian Federation, Smolensk 214012, RussiaPulmonology Department, Brach No 4 of FSGI «1586 MCH» of the Ministry of Defense of the Russian Federation, Smolensk 214012, RussiaLaboratory Molecular Diagnostics, Institute of Antimicrobial Chemotherapy, Smolensk State Medical University Federal State Budgetary Educational Institution of Higher Education «Smolensk State Medical University» of the Ministry of Healthcare of the Russian Federation, Smolensk 214019, RussiaWe evaluated the effect of macrolide-resistant mutations in the <i>Mycoplasma pneumoniae</i> 23S rRNA gene on the severity of lower respiratory tract infections in immunocompetent young adults treated at the Smolensk Military Hospital between 25 October 2017, and 17 November 2021. All analyzed cases represented a non-severe infection of the lower respiratory tract: 44 case histories with community-acquired pneumonia and 20 cases with acute bronchitis. The presence of mutations in the gene 23S rRNA of <i>M. pneumoniae</i> was determined with standard Sanger sequencing. The macrolide-resistant genotype was found in 4/44 (9.1%) of the samples of the patients with pneumonia and in 3/20 (15%) of the samples of the patients with acute bronchitis. The analyzed cases with identified <i>M. pneumoniae</i> carrying a mutation in the 23S rRNA gene did not show any differences in the clinical presentation in terms of disease severity caused by <i>M. pneumoniae</i> with the wild-type (WT) phenotype.https://www.mdpi.com/2076-0817/12/1/103community-acquired pneumonia<i>Mycoplasma pneumoniae</i>23S rRNAacute bronchitis |
| spellingShingle | Inna Alexandrovna Edelstein Olga Vladimirovna Ivanova Oleg Igorevich Romashov Roman Sergeevich Kozlov Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene Pathogens community-acquired pneumonia <i>Mycoplasma pneumoniae</i> 23S rRNA acute bronchitis |
| title | Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene |
| title_full | Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene |
| title_fullStr | Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene |
| title_full_unstemmed | Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene |
| title_short | Course of Lower Respiratory Tract Infection in Young People Treated at the Military Hospital of Smolensk Garrison with Detected <i>Mycoplasma pneumoniae</i> Carrying a Macrolide-Resistant Mutation in 23S rRNA Gene |
| title_sort | course of lower respiratory tract infection in young people treated at the military hospital of smolensk garrison with detected i mycoplasma pneumoniae i carrying a macrolide resistant mutation in 23s rrna gene |
| topic | community-acquired pneumonia <i>Mycoplasma pneumoniae</i> 23S rRNA acute bronchitis |
| url | https://www.mdpi.com/2076-0817/12/1/103 |
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