Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence
Every year millions of young people are treated with anaesthetic agents for surgery and sedation in a seemingly safe manner. However, growing and convincing preclinical evidence in rodents and nonhuman primates, together with recent epidemiological observations, suggest that exposure to anaesthetics...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-03-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3425/4/1/136 |
| _version_ | 1818138357003190272 |
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| author | Zhaowei Zhou Daqing Ma |
| author_facet | Zhaowei Zhou Daqing Ma |
| author_sort | Zhaowei Zhou |
| collection | DOAJ |
| description | Every year millions of young people are treated with anaesthetic agents for surgery and sedation in a seemingly safe manner. However, growing and convincing preclinical evidence in rodents and nonhuman primates, together with recent epidemiological observations, suggest that exposure to anaesthetics in common clinical use can be neurotoxic to the developing brain and lead to long-term neurological sequelae. These findings have seriously questioned the safe use of general anaesthetics in obstetric and paediatric patients. The mechanisms and human applicability of anaesthetic neurotoxicity and neuroprotection have remained under intense investigation over the past decade. Ongoing pre-clinical investigation may have significant impact on clinical practice in the near future. This review represents recent developments in this rapidly emerging field. The aim is to summarise recently available laboratory data, especially those being published after 2010, in the field of anaesthetics-induced neurotoxicity and its impact on cognitive function. In addition, we will discuss recent findings in mechanisms of early-life anaesthetics-induced neurotoxicity, the role of human stem cell-derived models in detecting such toxicity, and new potential alleviating strategies. |
| first_indexed | 2024-12-11T10:10:54Z |
| format | Article |
| id | doaj.art-3f52e4ccb87648c19baf3a3a3396851e |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-11T10:10:54Z |
| publishDate | 2014-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-3f52e4ccb87648c19baf3a3a3396851e2022-12-22T01:11:45ZengMDPI AGBrain Sciences2076-34252014-03-014113614910.3390/brainsci4010136brainsci4010136Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical EvidenceZhaowei Zhou0Daqing Ma1Section of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UKSection of Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery & Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UKEvery year millions of young people are treated with anaesthetic agents for surgery and sedation in a seemingly safe manner. However, growing and convincing preclinical evidence in rodents and nonhuman primates, together with recent epidemiological observations, suggest that exposure to anaesthetics in common clinical use can be neurotoxic to the developing brain and lead to long-term neurological sequelae. These findings have seriously questioned the safe use of general anaesthetics in obstetric and paediatric patients. The mechanisms and human applicability of anaesthetic neurotoxicity and neuroprotection have remained under intense investigation over the past decade. Ongoing pre-clinical investigation may have significant impact on clinical practice in the near future. This review represents recent developments in this rapidly emerging field. The aim is to summarise recently available laboratory data, especially those being published after 2010, in the field of anaesthetics-induced neurotoxicity and its impact on cognitive function. In addition, we will discuss recent findings in mechanisms of early-life anaesthetics-induced neurotoxicity, the role of human stem cell-derived models in detecting such toxicity, and new potential alleviating strategies.http://www.mdpi.com/2076-3425/4/1/136anaestheticsneuroapoptosisneurotoxicityneonatesdeveloping brain |
| spellingShingle | Zhaowei Zhou Daqing Ma Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence Brain Sciences anaesthetics neuroapoptosis neurotoxicity neonates developing brain |
| title | Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence |
| title_full | Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence |
| title_fullStr | Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence |
| title_full_unstemmed | Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence |
| title_short | Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence |
| title_sort | anaesthetics induced neurotoxicity in developing brain an update on preclinical evidence |
| topic | anaesthetics neuroapoptosis neurotoxicity neonates developing brain |
| url | http://www.mdpi.com/2076-3425/4/1/136 |
| work_keys_str_mv | AT zhaoweizhou anaestheticsinducedneurotoxicityindevelopingbrainanupdateonpreclinicalevidence AT daqingma anaestheticsinducedneurotoxicityindevelopingbrainanupdateonpreclinicalevidence |