A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice
Liver-related disease caused by alcohol is a frequent disorder of the hepatic tract. Heavy consumption of alcohol in a short period causes oxidative damage to the liver. Sea cucumber is abundant in nutrients and its various extracts have been studied for antioxidant properties. One peptide was isola...
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MDPI AG
2022-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/18/5839 |
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| author | Qiliang Zhu Huiling Zhuo Lamei Yang Haohong Ouyang Jun Chen Bing Liu Hongliang Huang |
| author_facet | Qiliang Zhu Huiling Zhuo Lamei Yang Haohong Ouyang Jun Chen Bing Liu Hongliang Huang |
| author_sort | Qiliang Zhu |
| collection | DOAJ |
| description | Liver-related disease caused by alcohol is a frequent disorder of the hepatic tract. Heavy consumption of alcohol in a short period causes oxidative damage to the liver. Sea cucumber is abundant in nutrients and its various extracts have been studied for antioxidant properties. One peptide was isolated and identified from <i>Apostichopus japonicus</i> in our recent study. We investigated the benefits of the peptide in a model of acute ethanol-induced male C57BL/6J mice. Dietary intake of the peptide could attenuate hepatomegaly, hepatitis and the accumulation of lipid droplets, and increase antioxidant enzyme activities in mice with acute alcoholic liver injury. The results indicated that a 20 mg/kg peptide supplement could activate the Nrf2/HO-1 pathway and block the nuclear translocation of NF-κB to alleviate oxidative stress and inflammation. In addition, the preventive effects of peptide supplementation may be related to autophagy. This study suggests that dietary supplementation with a sea cucumber-derived peptide is one of the potential candidates to alleviate acute alcoholic liver injury. |
| first_indexed | 2024-03-09T23:01:51Z |
| format | Article |
| id | doaj.art-3f5351b0236249d7b30092dd070b7d6d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:01:51Z |
| publishDate | 2022-09-01 |
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| series | Molecules |
| spelling | doaj.art-3f5351b0236249d7b30092dd070b7d6d2023-11-23T17:59:46ZengMDPI AGMolecules1420-30492022-09-012718583910.3390/molecules27185839A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J MiceQiliang Zhu0Huiling Zhuo1Lamei Yang2Haohong Ouyang3Jun Chen4Bing Liu5Hongliang Huang6School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Nursing, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Biosciences & Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Biosciences & Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Biosciences & Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaLiver-related disease caused by alcohol is a frequent disorder of the hepatic tract. Heavy consumption of alcohol in a short period causes oxidative damage to the liver. Sea cucumber is abundant in nutrients and its various extracts have been studied for antioxidant properties. One peptide was isolated and identified from <i>Apostichopus japonicus</i> in our recent study. We investigated the benefits of the peptide in a model of acute ethanol-induced male C57BL/6J mice. Dietary intake of the peptide could attenuate hepatomegaly, hepatitis and the accumulation of lipid droplets, and increase antioxidant enzyme activities in mice with acute alcoholic liver injury. The results indicated that a 20 mg/kg peptide supplement could activate the Nrf2/HO-1 pathway and block the nuclear translocation of NF-κB to alleviate oxidative stress and inflammation. In addition, the preventive effects of peptide supplementation may be related to autophagy. This study suggests that dietary supplementation with a sea cucumber-derived peptide is one of the potential candidates to alleviate acute alcoholic liver injury.https://www.mdpi.com/1420-3049/27/18/5839sea cucumberoxidative stressautophagyacute alcoholic liver injury |
| spellingShingle | Qiliang Zhu Huiling Zhuo Lamei Yang Haohong Ouyang Jun Chen Bing Liu Hongliang Huang A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice Molecules sea cucumber oxidative stress autophagy acute alcoholic liver injury |
| title | A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice |
| title_full | A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice |
| title_fullStr | A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice |
| title_full_unstemmed | A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice |
| title_short | A Peptide HEPFYGNEGALR from <i>Apostichopus japonicus</i> Alleviates Acute Alcoholic Liver Injury by Enhancing Antioxidant Response in Male C57BL/6J Mice |
| title_sort | peptide hepfygnegalr from i apostichopus japonicus i alleviates acute alcoholic liver injury by enhancing antioxidant response in male c57bl 6j mice |
| topic | sea cucumber oxidative stress autophagy acute alcoholic liver injury |
| url | https://www.mdpi.com/1420-3049/27/18/5839 |
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