Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs
A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/5/635 |
| _version_ | 1797536373270380544 |
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| author | Ding Li Menglong Wang Wen-Liang Song Deng-Guang Yu Sim Wan Annie Bligh |
| author_facet | Ding Li Menglong Wang Wen-Liang Song Deng-Guang Yu Sim Wan Annie Bligh |
| author_sort | Ding Li |
| collection | DOAJ |
| description | A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy. |
| first_indexed | 2024-03-10T11:58:47Z |
| format | Article |
| id | doaj.art-3f558c86379b4b70bc671f51829ae836 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T11:58:47Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3f558c86379b4b70bc671f51829ae8362023-11-21T17:03:18ZengMDPI AGBiomolecules2218-273X2021-04-0111563510.3390/biom11050635Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double DrugsDing Li0Menglong Wang1Wen-Liang Song2Deng-Guang Yu3Sim Wan Annie Bligh4School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, ChinaSchool of Health Sciences, Caritas Institute of Higher Education, Hong Kong 999077, ChinaA side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. X-ray diffraction demonstrated that all crystalline drugs loaded in Janus beads-on-a-string products were transferred into the amorphous state. ATR-FTIR revealed that the components of prepared Janus nanostructures were compatibility. In vitro dissolution tests showed that Janus beads-on-a-string products could provide typical double drugs controlled-release profiles, which provided a faster immediate release of MB and a slower sustained release of KET than the electrospun Janus nanofibers. Drug releases from the Janus beads-on-a-string products were controlled through a combination of erosion mechanism (linear MB-PVP sides) and a typical Fickian diffusion mechanism (bead KET-EC sides). This work developed a brand-new approach for the preparation of the Janus beads-on-a-string nanostructures using side-by-side electrospinning, and also provided a fresh idea for double drugs controlled release and the potential combined therapy.https://www.mdpi.com/2218-273X/11/5/635side-by-side electrospinningJanus structurebeads-on-a-stringimmediate releasesustained release |
| spellingShingle | Ding Li Menglong Wang Wen-Liang Song Deng-Guang Yu Sim Wan Annie Bligh Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs Biomolecules side-by-side electrospinning Janus structure beads-on-a-string immediate release sustained release |
| title | Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs |
| title_full | Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs |
| title_fullStr | Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs |
| title_full_unstemmed | Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs |
| title_short | Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs |
| title_sort | electrospun janus beads on a string structures for different types of controlled release profiles of double drugs |
| topic | side-by-side electrospinning Janus structure beads-on-a-string immediate release sustained release |
| url | https://www.mdpi.com/2218-273X/11/5/635 |
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