| Summary: | The objective of this study was to perform in vitro and in
silico studies with essential oils in order to search bioactive substances
with potential anti-H. pylori activity. The methodology for in vitro
studies was based on the use of soy urease, chosen as a model system
to study the effect of potential inhibitors of urease. The major
constituents of the evaluated essential oils were subjected to studies
of molecular docking with the urease enzyme (PDB 1E9Z). The results
suggest that eucalyptol, geranial and D-limomene can act as urease
inhibitors to interact in the active site of the enzyme. This study
concludes that essential oils can be considered promising sources of
bioactive substances with inhibitory effect on H. pylori urease activity.
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