EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICO
The objective of this study was to perform in vitro and in silico studies with essential oils in order to search bioactive substances with potential anti-H. pylori activity. The methodology for in vitro studies was based on the use of soy urease, chosen as a model system to study the effect of p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Portuguese |
| Published: |
Universidade do Oeste Paulista
2015-09-01
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| Series: | Colloquium Exactarum |
| Subjects: | |
| Online Access: | http://revistas.unoeste.br/revistas/ojs/index.php/ce/article/view/1442/1475 |
| _version_ | 1828920940975620096 |
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| author | Deisiane Aparecida da Silva Flavianny Brencis da Silva Mikalousk Rubia Michele Suzuki Rafaelle Bonzanini Romero Adriano Lopes Romero |
| author_facet | Deisiane Aparecida da Silva Flavianny Brencis da Silva Mikalousk Rubia Michele Suzuki Rafaelle Bonzanini Romero Adriano Lopes Romero |
| author_sort | Deisiane Aparecida da Silva |
| collection | DOAJ |
| description | The objective of this study was to perform in vitro and in
silico studies with essential oils in order to search bioactive substances
with potential anti-H. pylori activity. The methodology for in vitro
studies was based on the use of soy urease, chosen as a model system
to study the effect of potential inhibitors of urease. The major
constituents of the evaluated essential oils were subjected to studies
of molecular docking with the urease enzyme (PDB 1E9Z). The results
suggest that eucalyptol, geranial and D-limomene can act as urease
inhibitors to interact in the active site of the enzyme. This study
concludes that essential oils can be considered promising sources of
bioactive substances with inhibitory effect on H. pylori urease activity. |
| first_indexed | 2024-12-13T21:55:22Z |
| format | Article |
| id | doaj.art-3f5611c959094de087fa8d14bd78a58d |
| institution | Directory Open Access Journal |
| issn | 2178-8332 |
| language | Portuguese |
| last_indexed | 2024-12-13T21:55:22Z |
| publishDate | 2015-09-01 |
| publisher | Universidade do Oeste Paulista |
| record_format | Article |
| series | Colloquium Exactarum |
| spelling | doaj.art-3f5611c959094de087fa8d14bd78a58d2022-12-21T23:30:10ZporUniversidade do Oeste PaulistaColloquium Exactarum2178-83322015-09-0107033947EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICODeisiane Aparecida da Silva0Flavianny Brencis da Silva Mikalousk1Rubia Michele Suzuki2Rafaelle Bonzanini Romero3Adriano Lopes Romero4Universidade Tecnológica Federal do ParanáUniversidade Tecnológica Federal do ParanáUniversidade Tecnológica Federal do ParanáUniversidade Tecnológica Federal do ParanáUniversidade Tecnológica Federal do ParanáThe objective of this study was to perform in vitro and in silico studies with essential oils in order to search bioactive substances with potential anti-H. pylori activity. The methodology for in vitro studies was based on the use of soy urease, chosen as a model system to study the effect of potential inhibitors of urease. The major constituents of the evaluated essential oils were subjected to studies of molecular docking with the urease enzyme (PDB 1E9Z). The results suggest that eucalyptol, geranial and D-limomene can act as urease inhibitors to interact in the active site of the enzyme. This study concludes that essential oils can be considered promising sources of bioactive substances with inhibitory effect on H. pylori urease activity.http://revistas.unoeste.br/revistas/ojs/index.php/ce/article/view/1442/1475Essential OilsUreaseEnzymatic InhibitionIn Silico StudyHelicobacter Pylori |
| spellingShingle | Deisiane Aparecida da Silva Flavianny Brencis da Silva Mikalousk Rubia Michele Suzuki Rafaelle Bonzanini Romero Adriano Lopes Romero EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICO Colloquium Exactarum Essential Oils Urease Enzymatic Inhibition In Silico Study Helicobacter Pylori |
| title | EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICO |
| title_full | EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICO |
| title_fullStr | EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICO |
| title_full_unstemmed | EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICO |
| title_short | EFEITO DE ÓLEOS ESSENCIAIS SOBRE A ENZIMA UREASE: UM ESTUDO IN VITRO E IN SILICO |
| title_sort | efeito de oleos essenciais sobre a enzima urease um estudo in vitro e in silico |
| topic | Essential Oils Urease Enzymatic Inhibition In Silico Study Helicobacter Pylori |
| url | http://revistas.unoeste.br/revistas/ojs/index.php/ce/article/view/1442/1475 |
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