The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network
Altered connectivity within and between the resting-state networks (RSNs) brought about by anesthetics that induce altered consciousness remains incompletely understood. It is known that the dorsal attention network (DAN) and its anticorrelations with other RSNs have been implicated in consciousness...
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MDPI AG
2021-08-01
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| author | Junkai Wang Yachao Xu Gopikrishna Deshpande Kuncheng Li Pei Sun Peipeng Liang |
| author_facet | Junkai Wang Yachao Xu Gopikrishna Deshpande Kuncheng Li Pei Sun Peipeng Liang |
| author_sort | Junkai Wang |
| collection | DOAJ |
| description | Altered connectivity within and between the resting-state networks (RSNs) brought about by anesthetics that induce altered consciousness remains incompletely understood. It is known that the dorsal attention network (DAN) and its anticorrelations with other RSNs have been implicated in consciousness. However, the role of DAN-related functional patterns in drug-induced sedative effects is less clear. In the current study, we investigated altered functional connectivity of the DAN during midazolam-induced light sedation. In a placebo-controlled and within-subjects experimental study, fourteen healthy volunteers received midazolam or saline with a 1-week interval. Resting-state fMRI data were acquired before and after intravenous drug administration. A multiple region of interest-driven analysis was employed to investigate connectivity within and between RSNs. It was found that functional connectivity was significantly decreased by midazolam injection in two regions located in the left inferior parietal lobule and the left middle temporal area within the DAN as compared with the saline condition. We also identified three clusters in anticorrelation between the DAN and other RSNs for the interaction effect, which included the left medial prefrontal cortex, the right superior temporal gyrus, and the right superior frontal gyrus. Connectivity between all regions and DAN was significantly decreased by midazolam injection. The sensorimotor network was minimally affected. Midazolam decreased functional connectivity of the dorsal attention network. These findings advance the understanding of the neural mechanism of sedation, and such functional patterns might have clinical implications in other medical conditions related to patients with cognitive impairment. |
| first_indexed | 2024-03-10T08:57:20Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T08:57:20Z |
| publishDate | 2021-08-01 |
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| series | Brain Sciences |
| spelling | doaj.art-3f5715d35dd74fb59020934ede05cf722023-11-22T07:00:10ZengMDPI AGBrain Sciences2076-34252021-08-01118110710.3390/brainsci11081107The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention NetworkJunkai Wang0Yachao Xu1Gopikrishna Deshpande2Kuncheng Li3Pei Sun4Peipeng Liang5Department of Psychology, Tsinghua University, Haidian District, Beijing 100084, ChinaDepartment of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaSchool of Psychology, Capital Normal University, Haidian District, Beijing 100048, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, ChinaDepartment of Psychology, Tsinghua University, Haidian District, Beijing 100084, ChinaSchool of Psychology, Capital Normal University, Haidian District, Beijing 100048, ChinaAltered connectivity within and between the resting-state networks (RSNs) brought about by anesthetics that induce altered consciousness remains incompletely understood. It is known that the dorsal attention network (DAN) and its anticorrelations with other RSNs have been implicated in consciousness. However, the role of DAN-related functional patterns in drug-induced sedative effects is less clear. In the current study, we investigated altered functional connectivity of the DAN during midazolam-induced light sedation. In a placebo-controlled and within-subjects experimental study, fourteen healthy volunteers received midazolam or saline with a 1-week interval. Resting-state fMRI data were acquired before and after intravenous drug administration. A multiple region of interest-driven analysis was employed to investigate connectivity within and between RSNs. It was found that functional connectivity was significantly decreased by midazolam injection in two regions located in the left inferior parietal lobule and the left middle temporal area within the DAN as compared with the saline condition. We also identified three clusters in anticorrelation between the DAN and other RSNs for the interaction effect, which included the left medial prefrontal cortex, the right superior temporal gyrus, and the right superior frontal gyrus. Connectivity between all regions and DAN was significantly decreased by midazolam injection. The sensorimotor network was minimally affected. Midazolam decreased functional connectivity of the dorsal attention network. These findings advance the understanding of the neural mechanism of sedation, and such functional patterns might have clinical implications in other medical conditions related to patients with cognitive impairment.https://www.mdpi.com/2076-3425/11/8/1107resting-state fMRIbetween-network anticorrelationdorsal attention networkmidazolamsedation |
| spellingShingle | Junkai Wang Yachao Xu Gopikrishna Deshpande Kuncheng Li Pei Sun Peipeng Liang The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network Brain Sciences resting-state fMRI between-network anticorrelation dorsal attention network midazolam sedation |
| title | The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network |
| title_full | The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network |
| title_fullStr | The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network |
| title_full_unstemmed | The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network |
| title_short | The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network |
| title_sort | effect of light sedation with midazolam on functional connectivity of the dorsal attention network |
| topic | resting-state fMRI between-network anticorrelation dorsal attention network midazolam sedation |
| url | https://www.mdpi.com/2076-3425/11/8/1107 |
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