THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATS
This study aimed to investigate alterations in hemorheology induced by L-carnosine, an anti- oxidant dipeptide, and to determine their relationship to oxidative stress in density-separated erythrocytes of aged and young rats. 28 male Sprague Dawley rats were divided into 4 groups as aged (Aca), youn...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2013-01-01
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| Series: | Acta Medica |
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| Online Access: | https://actamedica.lfhk.cuni.cz/56/1/0023/ |
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| author | Gülten Erken Melek Bor-Kucukatay Emine KilicToprak Beyza Akdag Vural Kucukatay |
| author_facet | Gülten Erken Melek Bor-Kucukatay Emine KilicToprak Beyza Akdag Vural Kucukatay |
| author_sort | Gülten Erken |
| collection | DOAJ |
| description | This study aimed to investigate alterations in hemorheology induced by L-carnosine, an anti- oxidant dipeptide, and to determine their relationship to oxidative stress in density-separated erythrocytes of aged and young rats. 28 male Sprague Dawley rats were divided into 4 groups as aged (Aca), young (Yca) L-carnosine groups (250 mg/kg L-carnosine, i.p.) and aged (As), young (Ys) control groups (saline, i.p.). Density separation was further performed to these groups in order to separate erythrocytes according to their age. Blood samples were used for the determination of erythrocyte deformability, aggregation; and oxidative stress parameters. Erythrocyte deformability of Yca group measured at 0.53 Pa was lower than Aca group. Similarly, deformability of least-dense (young) erythrocytes of Yca group was decreased compared to least-dense erythrocytes of Aca groups. Total antioxidant capacity (TAC) of Aca group was higher and oxidative stress index (OSI) lower than As group. Although L-carnosine resulted in an enhancement in TAC of aged rats, this favorable effect was not observed in erythrocyte deformability and aggregation in the dose applied in this study. |
| first_indexed | 2024-04-14T06:17:35Z |
| format | Article |
| id | doaj.art-3f57d4d4d53a4a67bca40572e5ff8e1f |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-14T06:17:35Z |
| publishDate | 2013-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-3f57d4d4d53a4a67bca40572e5ff8e1f2022-12-22T02:08:09ZengKarolinum PressActa Medica1211-42861805-96942013-01-01561232810.14712/18059694.2014.34THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATSGülten Erken0Melek Bor-Kucukatay1Emine KilicToprak2Beyza Akdag3Vural Kucukatay4Balikesir University, Faculty of Medicine, Department of Physiology, Balikesir, TurkeyPamukkale University, Faculty of Medicine, Department of Physiology, Kinikli, Denizli, TurkeyPamukkale University, Faculty of Medicine, Department of Physiology, Kinikli, Denizli, TurkeyPamukkale University, Faculty of Medicine, Department of Biostatistics, Kinikli, Denizli, TurkeyPamukkale University, Faculty of Medicine, Department of Physiology, Kinikli, Denizli, TurkeyThis study aimed to investigate alterations in hemorheology induced by L-carnosine, an anti- oxidant dipeptide, and to determine their relationship to oxidative stress in density-separated erythrocytes of aged and young rats. 28 male Sprague Dawley rats were divided into 4 groups as aged (Aca), young (Yca) L-carnosine groups (250 mg/kg L-carnosine, i.p.) and aged (As), young (Ys) control groups (saline, i.p.). Density separation was further performed to these groups in order to separate erythrocytes according to their age. Blood samples were used for the determination of erythrocyte deformability, aggregation; and oxidative stress parameters. Erythrocyte deformability of Yca group measured at 0.53 Pa was lower than Aca group. Similarly, deformability of least-dense (young) erythrocytes of Yca group was decreased compared to least-dense erythrocytes of Aca groups. Total antioxidant capacity (TAC) of Aca group was higher and oxidative stress index (OSI) lower than As group. Although L-carnosine resulted in an enhancement in TAC of aged rats, this favorable effect was not observed in erythrocyte deformability and aggregation in the dose applied in this study.https://actamedica.lfhk.cuni.cz/56/1/0023/Aged ratL-carnosineDensity separationErythrocyte deformabilityTotal antioxidant statusTotal oxidant status |
| spellingShingle | Gülten Erken Melek Bor-Kucukatay Emine KilicToprak Beyza Akdag Vural Kucukatay THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATS Acta Medica Aged rat L-carnosine Density separation Erythrocyte deformability Total antioxidant status Total oxidant status |
| title | THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATS |
| title_full | THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATS |
| title_fullStr | THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATS |
| title_full_unstemmed | THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATS |
| title_short | THE EFFECT OF L-CARNOSINE ON ERYTHROCYTE DEFORMABILITY AND AGGREGATION ACCORDING TO THE CELL AGE IN YOUNG AND AGED RATS |
| title_sort | effect of l carnosine on erythrocyte deformability and aggregation according to the cell age in young and aged rats |
| topic | Aged rat L-carnosine Density separation Erythrocyte deformability Total antioxidant status Total oxidant status |
| url | https://actamedica.lfhk.cuni.cz/56/1/0023/ |
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