Phosphatase inhibition by sodium orthovanadate displays anti-inflammatory action by suppressing AKT-IKKβ signaling in RAW264.7 cells

Phosphatase inhibition by sodium orthovanadate displays anti-inflammatory action by suppressing AKT-IKKβ signaling in RAW264.7 cells

Sodium orthovanadate (Na3VO4) is an inhibitor of phosphatases that acts as a phosphate analog and is being developed as an anti-diabetes drug. Phosphatases play important roles in inflammatory signal pathways by modulating the removal of phosphate moieties of key signaling proteins. However, the rol...

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Bibliographic Details
Main Authors: Han Gyung Kim, Seong-Gu Jeong, Ji Hye Kim, Jae Youl Cho
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
Sodium orthovanadate
NF-κB signaling
IKKα/β
AKT1/2
Protein phosphatases
Inflammatory responses
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022001950

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http://www.sciencedirect.com/science/article/pii/S2214750022001950

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