Review of dengue, zika and chikungunya infections in nervous system in endemic areas
Dengue, zika, and chikungunya are arboviruses of great epidemiological relevance worldwide. The emergence and re-emergence of viral infections transmitted by mosquitoes constitute a serious human public health problem. The neurological manifestations caused by these viruses have a high potential for...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
2023-12-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777104 |
| _version_ | 1797372140703449088 |
|---|---|
| author | Marzia Puccioni-Sohler Cristiane Nascimento Soares Paulo Pereira Christo Sérgio Monteiro de Almeida |
| author_facet | Marzia Puccioni-Sohler Cristiane Nascimento Soares Paulo Pereira Christo Sérgio Monteiro de Almeida |
| author_sort | Marzia Puccioni-Sohler |
| collection | DOAJ |
| description | Dengue, zika, and chikungunya are arboviruses of great epidemiological relevance worldwide. The emergence and re-emergence of viral infections transmitted by mosquitoes constitute a serious human public health problem. The neurological manifestations caused by these viruses have a high potential for death or sequelae. The complications that occur in the nervous system associated with arboviruses can be a challenge for diagnosis and treatment. In endemic areas, suspected cases should include acute encephalitis, myelitis, encephalomyelitis, polyradiculoneuritis, and/or other syndromes of the central or peripheral nervous system, in the absence of a known explanation. The confirmation diagnosis is based on viral (isolation or RT-PCR) or antigens detection in tissues, blood, cerebrospinal fluid, or other body fluids, increase in IgG antibody titers between paired serum samples, specific IgM antibody in cerebrospinal fluid and serological conversion to IgM between paired serum samples (non-reactive in the acute phase and reactive in the convalescent). The cerebrospinal fluid examination can demonstrate: 1. etiological agent; 2. inflammatory reaction or protein-cytological dissociation depending on the neurological condition; 3. specific IgM, 4. intrathecal synthesis of specific IgG (dengue and chikungunya); 5. exclusion of other infectious agents. The treatment of neurological complications aims to improve the symptoms, while the vaccine represents the great hope for the control and prevention of neuroinvasive arboviruses. This narrative review summarizes the updated epidemiology, general features, neuropathogenesis, and neurological manifestations associated with dengue, zika, and chikungunya infection. |
| first_indexed | 2024-03-08T18:31:35Z |
| format | Article |
| id | doaj.art-3f5ba06137d94f80893da0735f7c19a8 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-03-08T18:31:35Z |
| publishDate | 2023-12-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-3f5ba06137d94f80893da0735f7c19a82023-12-30T00:06:05ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272023-12-0181121112112410.1055/s-0043-1777104Review of dengue, zika and chikungunya infections in nervous system in endemic areasMarzia Puccioni-Sohler0https://orcid.org/0000-0001-6007-9142Cristiane Nascimento Soares1https://orcid.org/0000-0001-7678-4006Paulo Pereira Christo2https://orcid.org/0000-0003-1224-5243Sérgio Monteiro de Almeida3https://orcid.org/0000-0001-5690-105XUniversidade Federal do Estado do Rio de Janeiro, Escola de Medicina e Cirurgia, Departamento de Medicina Geral, Rio de Janeiro RJ, Brazil.Hospital Federal dos Servidores do Estado, Rio de Janeiro RJ, Brazil.Santa Casa BH, Faculdade de Saúde, Programa de Pós-Graduação Stricto Sensu em Medicina-Biomedicina, Belo Horizonte MG, Brazil.Universidade Federal do Paraná, Faculdade de Medicina, Departamento de Patologia Médica, Curitiba PR, Brazil.Dengue, zika, and chikungunya are arboviruses of great epidemiological relevance worldwide. The emergence and re-emergence of viral infections transmitted by mosquitoes constitute a serious human public health problem. The neurological manifestations caused by these viruses have a high potential for death or sequelae. The complications that occur in the nervous system associated with arboviruses can be a challenge for diagnosis and treatment. In endemic areas, suspected cases should include acute encephalitis, myelitis, encephalomyelitis, polyradiculoneuritis, and/or other syndromes of the central or peripheral nervous system, in the absence of a known explanation. The confirmation diagnosis is based on viral (isolation or RT-PCR) or antigens detection in tissues, blood, cerebrospinal fluid, or other body fluids, increase in IgG antibody titers between paired serum samples, specific IgM antibody in cerebrospinal fluid and serological conversion to IgM between paired serum samples (non-reactive in the acute phase and reactive in the convalescent). The cerebrospinal fluid examination can demonstrate: 1. etiological agent; 2. inflammatory reaction or protein-cytological dissociation depending on the neurological condition; 3. specific IgM, 4. intrathecal synthesis of specific IgG (dengue and chikungunya); 5. exclusion of other infectious agents. The treatment of neurological complications aims to improve the symptoms, while the vaccine represents the great hope for the control and prevention of neuroinvasive arboviruses. This narrative review summarizes the updated epidemiology, general features, neuropathogenesis, and neurological manifestations associated with dengue, zika, and chikungunya infection.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777104ArbovirusesDengueZika VirusChikungunya VirusNeurologic ManifestationsEncephalitis VirusesCerebrospinal FluidArbovírusDengueZika VírusVírus ChikungunyaManifestações NeurológicasVírus da EncefaliteLíquido Cefalorraquidiano |
| spellingShingle | Marzia Puccioni-Sohler Cristiane Nascimento Soares Paulo Pereira Christo Sérgio Monteiro de Almeida Review of dengue, zika and chikungunya infections in nervous system in endemic areas Arquivos de Neuro-Psiquiatria Arboviruses Dengue Zika Virus Chikungunya Virus Neurologic Manifestations Encephalitis Viruses Cerebrospinal Fluid Arbovírus Dengue Zika Vírus Vírus Chikungunya Manifestações Neurológicas Vírus da Encefalite Líquido Cefalorraquidiano |
| title | Review of dengue, zika and chikungunya infections in nervous system in endemic areas |
| title_full | Review of dengue, zika and chikungunya infections in nervous system in endemic areas |
| title_fullStr | Review of dengue, zika and chikungunya infections in nervous system in endemic areas |
| title_full_unstemmed | Review of dengue, zika and chikungunya infections in nervous system in endemic areas |
| title_short | Review of dengue, zika and chikungunya infections in nervous system in endemic areas |
| title_sort | review of dengue zika and chikungunya infections in nervous system in endemic areas |
| topic | Arboviruses Dengue Zika Virus Chikungunya Virus Neurologic Manifestations Encephalitis Viruses Cerebrospinal Fluid Arbovírus Dengue Zika Vírus Vírus Chikungunya Manifestações Neurológicas Vírus da Encefalite Líquido Cefalorraquidiano |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777104 |
| work_keys_str_mv | AT marziapuccionisohler reviewofdenguezikaandchikungunyainfectionsinnervoussysteminendemicareas AT cristianenascimentosoares reviewofdenguezikaandchikungunyainfectionsinnervoussysteminendemicareas AT paulopereirachristo reviewofdenguezikaandchikungunyainfectionsinnervoussysteminendemicareas AT sergiomonteirodealmeida reviewofdenguezikaandchikungunyainfectionsinnervoussysteminendemicareas |