Interferon-Mediated Innate Immune Responses against Malaria Parasite Liver Stages

Interferon-Mediated Innate Immune Responses against Malaria Parasite Liver Stages

Summary: Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage inf...

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Bibliographic Details
Main Authors: Jessica L. Miller, Brandon K. Sack, Michael Baldwin, Ashley M. Vaughan, Stefan H.I. Kappe
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400196X

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