Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target
Caveolin-1 (Cav-1) is an integral scaffolding membrane protein found in most cell types. Cav-1 has been found to contribute significantly to ocular function, with mutations of Cav-1 being associated with a genetic risk of glaucoma development. Raised intraocular pressure (IOP) is a major modifiable...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1087123/full |
| _version_ | 1797944960511639552 |
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| author | Jing Hong Loo Zhaoran Wang Rachel S. Chong Rachel S. Chong |
| author_facet | Jing Hong Loo Zhaoran Wang Rachel S. Chong Rachel S. Chong |
| author_sort | Jing Hong Loo |
| collection | DOAJ |
| description | Caveolin-1 (Cav-1) is an integral scaffolding membrane protein found in most cell types. Cav-1 has been found to contribute significantly to ocular function, with mutations of Cav-1 being associated with a genetic risk of glaucoma development. Raised intraocular pressure (IOP) is a major modifiable risk factor for glaucoma. Cav-1 may be involved in both IOP-dependent and independent mechanisms involving vascular dysregulation. Systemic vascular diseases including hypertension, diabetes and hyperlipidaemia, have been shown to be associated with glaucoma development. Cav-1 is closely interlinked with endothelial nitric oxide synthase pathways that mediate vascular function and prevent cardiovascular diseases. Endothelial nitric oxide synthase and endothelin-1 are key vasoactive molecules expressed in retinal blood vessels that function to autoregulate ocular blood flow (OBF). Disruptions in the homeostasis of OBF have led to a growing concept of impaired neurovascular coupling in glaucoma. The imbalance between perfusion and neuronal stimulation arising from Cav-1 depletion may result in relative ischemia of the optic nerve head and glaucomatous injury. OBF is also governed by circadian variation in IOP and systemic blood pressure (BP). Cav-1 has been shown to influence central BP variability and other circadian rhythms such as the diurnal phagolysosomal digestion of photoreceptor fragments and toxic substrates to maintain ocular health. Overall, the vast implications of Cav-1 on various ocular mechanisms leading to glaucoma suggest a potential for new therapeutics to enhance Cav-1 expression, which has seen success in other neurodegenerative diseases. |
| first_indexed | 2024-04-10T20:46:47Z |
| format | Article |
| id | doaj.art-3f5ce40e9b3647edbf447432cdded81b |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T20:46:47Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3f5ce40e9b3647edbf447432cdded81b2023-01-24T05:58:18ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-011010.3389/fmed.2023.10871231087123Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic targetJing Hong Loo0Zhaoran Wang1Rachel S. Chong2Rachel S. Chong3Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDuke-NUS Medical School, Singapore, SingaporeGlaucoma Department, Singapore National Eye Center, Singapore, SingaporeOcular Imaging Department, Singapore Eye Research Institute, Singapore, SingaporeCaveolin-1 (Cav-1) is an integral scaffolding membrane protein found in most cell types. Cav-1 has been found to contribute significantly to ocular function, with mutations of Cav-1 being associated with a genetic risk of glaucoma development. Raised intraocular pressure (IOP) is a major modifiable risk factor for glaucoma. Cav-1 may be involved in both IOP-dependent and independent mechanisms involving vascular dysregulation. Systemic vascular diseases including hypertension, diabetes and hyperlipidaemia, have been shown to be associated with glaucoma development. Cav-1 is closely interlinked with endothelial nitric oxide synthase pathways that mediate vascular function and prevent cardiovascular diseases. Endothelial nitric oxide synthase and endothelin-1 are key vasoactive molecules expressed in retinal blood vessels that function to autoregulate ocular blood flow (OBF). Disruptions in the homeostasis of OBF have led to a growing concept of impaired neurovascular coupling in glaucoma. The imbalance between perfusion and neuronal stimulation arising from Cav-1 depletion may result in relative ischemia of the optic nerve head and glaucomatous injury. OBF is also governed by circadian variation in IOP and systemic blood pressure (BP). Cav-1 has been shown to influence central BP variability and other circadian rhythms such as the diurnal phagolysosomal digestion of photoreceptor fragments and toxic substrates to maintain ocular health. Overall, the vast implications of Cav-1 on various ocular mechanisms leading to glaucoma suggest a potential for new therapeutics to enhance Cav-1 expression, which has seen success in other neurodegenerative diseases.https://www.frontiersin.org/articles/10.3389/fmed.2023.1087123/fullglaucomaCaveolin-1 (Cav-1)systemic vascular risk factorsocular blood flowneurovascular coupling (NVC)glaucoma therapy |
| spellingShingle | Jing Hong Loo Zhaoran Wang Rachel S. Chong Rachel S. Chong Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target Frontiers in Medicine glaucoma Caveolin-1 (Cav-1) systemic vascular risk factors ocular blood flow neurovascular coupling (NVC) glaucoma therapy |
| title | Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target |
| title_full | Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target |
| title_fullStr | Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target |
| title_full_unstemmed | Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target |
| title_short | Caveolin-1 in vascular health and glaucoma: A critical vascular regulator and potential therapeutic target |
| title_sort | caveolin 1 in vascular health and glaucoma a critical vascular regulator and potential therapeutic target |
| topic | glaucoma Caveolin-1 (Cav-1) systemic vascular risk factors ocular blood flow neurovascular coupling (NVC) glaucoma therapy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1087123/full |
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