Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review
Coronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SE...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1275696/full |
| _version_ | 1827778805214740480 |
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| author | Kentaro Kawama Rui Shimazaki Yoko Sunami Natsuki Miyakoshi Shinsuke Tobisawa Toshio Shimizu Kazushi Takahashi |
| author_facet | Kentaro Kawama Rui Shimazaki Yoko Sunami Natsuki Miyakoshi Shinsuke Tobisawa Toshio Shimizu Kazushi Takahashi |
| author_sort | Kentaro Kawama |
| collection | DOAJ |
| description | Coronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SEPs contributed to diagnosing myelitis in the present patients. The SEP findings improved as the neurological symptoms improved. Despite a delay in initiating immunosuppressive treatment after myelitis onset, all the patients improved clinically. In the light of recent progress in COVID-19 research, several hypotheses can be made to explain the pathophysiology underlying MRI-negative myelitis, including antibody-binding and microglial synapse elimination. |
| first_indexed | 2024-03-11T14:39:52Z |
| format | Article |
| id | doaj.art-3f5e20feb0524c019b33b9c747786f62 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T14:39:52Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-3f5e20feb0524c019b33b9c747786f622023-10-30T15:23:55ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12756961275696Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature reviewKentaro KawamaRui ShimazakiYoko SunamiNatsuki MiyakoshiShinsuke TobisawaToshio ShimizuKazushi TakahashiCoronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SEPs contributed to diagnosing myelitis in the present patients. The SEP findings improved as the neurological symptoms improved. Despite a delay in initiating immunosuppressive treatment after myelitis onset, all the patients improved clinically. In the light of recent progress in COVID-19 research, several hypotheses can be made to explain the pathophysiology underlying MRI-negative myelitis, including antibody-binding and microglial synapse elimination.https://www.frontiersin.org/articles/10.3389/fneur.2023.1275696/fullCOVID-19myelitisSEPsMRImicroglia |
| spellingShingle | Kentaro Kawama Rui Shimazaki Yoko Sunami Natsuki Miyakoshi Shinsuke Tobisawa Toshio Shimizu Kazushi Takahashi Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review Frontiers in Neurology COVID-19 myelitis SEPs MRI microglia |
| title | Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review |
| title_full | Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review |
| title_fullStr | Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review |
| title_full_unstemmed | Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review |
| title_short | Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review |
| title_sort | case report mri negative myelitis following covid 19 with sep abnormalities a case series and literature review |
| topic | COVID-19 myelitis SEPs MRI microglia |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1275696/full |
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