In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [<sup>11</sup>C]OCM-44 and [<sup>18</sup>F]OCM-50 in Non-Human Primates

In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [<sup>11</sup>C]OCM-44 and [<sup>18</sup>F]OCM-50 in Non-Human Primates

Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [<sup>11</sup>C]OCM-44 and [<sup>18</sup>F...

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Bibliographic Details
Main Authors: Kelly Smart, Ming-Qiang Zheng, Daniel Holden, Zachary Felchner, Li Zhang, Yanjiang Han, Jim Ropchan, Richard E. Carson, Neil Vasdev, Yiyun Huang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
positron emission tomography
radiopharmaceutical
glycogen synthase kinase 3
non-human primates
Online Access:https://www.mdpi.com/1424-8247/16/2/194

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