The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis.

The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis.

Leishmania spp. are trypanosomatid parasites that replicate intracellularly in macrophages, causing serious human morbidity and mortality throughout the world. Trypanosomatid protozoa cannot synthesize heme, so must acquire this essential cofactor from their environment. Earlier studies identified L...

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Bibliographic Details
Main Authors: Rebecca L Renberg, Xiaojing Yuan, Tamika K Samuel, Danilo C Miguel, Iqbal Hamza, Norma W Andrews, Andrew R Flannery
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4441390?pdf=render

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