The neuroprotective effect of dexmedetomidine and its mechanism
Dexmedetomidine (DEX) is a highly selective α2 receptor agonist that is routinely used in the clinic for sedation and anesthesia. Recently, an increasing number of studies have shown that DEX has a protective effect against brain injury caused by traumatic brain injury (TBI), subarachnoid hemorrhage...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.965661/full |
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| author | Yijun Hu Yijun Hu Hong Zhou Huanxin Zhang Yunlong Sui Zhen Zhang Yuntao Zou Kunquan Li Yunyi Zhao Jiangbo Xie Lunzhong Zhang |
| author_facet | Yijun Hu Yijun Hu Hong Zhou Huanxin Zhang Yunlong Sui Zhen Zhang Yuntao Zou Kunquan Li Yunyi Zhao Jiangbo Xie Lunzhong Zhang |
| author_sort | Yijun Hu |
| collection | DOAJ |
| description | Dexmedetomidine (DEX) is a highly selective α2 receptor agonist that is routinely used in the clinic for sedation and anesthesia. Recently, an increasing number of studies have shown that DEX has a protective effect against brain injury caused by traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), cerebral ischemia and ischemia–reperfusion (I/R), suggesting its potential as a neuroprotective agent. Here, we summarized the neuroprotective effects of DEX in several models of neurological damage and examined its mechanism based on the current literature. Ultimately, we found that the neuroprotective effect of DEX mainly involved inhibition of inflammatory reactions, reduction of apoptosis and autophagy, and protection of the blood–brain barrier and enhancement of stable cell structures in five way. Therefore, DEX can provide a crucial advantage in neurological recovery for patients with brain injury. The purpose of this study was to further clarify the neuroprotective mechanisms of DEX therefore suggesting its potential in the clinical management of the neurological injuries. |
| first_indexed | 2024-04-12T20:40:20Z |
| format | Article |
| id | doaj.art-3f60d76e3ffc4fcfb8c9bdd0ccb14a75 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T20:40:20Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-3f60d76e3ffc4fcfb8c9bdd0ccb14a752022-12-22T03:17:26ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.965661965661The neuroprotective effect of dexmedetomidine and its mechanismYijun Hu0Yijun Hu1Hong Zhou2Huanxin Zhang3Yunlong Sui4Zhen Zhang5Yuntao Zou6Kunquan Li7Yunyi Zhao8Jiangbo Xie9Lunzhong Zhang10Neurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaGraduate School, Shandong University of Traditional Chinese Medicine, Jinan, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaNeurology Department, Weifang Hospital of Traditional Chinese Medicine, Weifang, ChinaDexmedetomidine (DEX) is a highly selective α2 receptor agonist that is routinely used in the clinic for sedation and anesthesia. Recently, an increasing number of studies have shown that DEX has a protective effect against brain injury caused by traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), cerebral ischemia and ischemia–reperfusion (I/R), suggesting its potential as a neuroprotective agent. Here, we summarized the neuroprotective effects of DEX in several models of neurological damage and examined its mechanism based on the current literature. Ultimately, we found that the neuroprotective effect of DEX mainly involved inhibition of inflammatory reactions, reduction of apoptosis and autophagy, and protection of the blood–brain barrier and enhancement of stable cell structures in five way. Therefore, DEX can provide a crucial advantage in neurological recovery for patients with brain injury. The purpose of this study was to further clarify the neuroprotective mechanisms of DEX therefore suggesting its potential in the clinical management of the neurological injuries.https://www.frontiersin.org/articles/10.3389/fphar.2022.965661/fulldexmedetomidineneuroprotectiveinflammatory responsecell apoptosisblood-brain barriercell structure protection |
| spellingShingle | Yijun Hu Yijun Hu Hong Zhou Huanxin Zhang Yunlong Sui Zhen Zhang Yuntao Zou Kunquan Li Yunyi Zhao Jiangbo Xie Lunzhong Zhang The neuroprotective effect of dexmedetomidine and its mechanism Frontiers in Pharmacology dexmedetomidine neuroprotective inflammatory response cell apoptosis blood-brain barrier cell structure protection |
| title | The neuroprotective effect of dexmedetomidine and its mechanism |
| title_full | The neuroprotective effect of dexmedetomidine and its mechanism |
| title_fullStr | The neuroprotective effect of dexmedetomidine and its mechanism |
| title_full_unstemmed | The neuroprotective effect of dexmedetomidine and its mechanism |
| title_short | The neuroprotective effect of dexmedetomidine and its mechanism |
| title_sort | neuroprotective effect of dexmedetomidine and its mechanism |
| topic | dexmedetomidine neuroprotective inflammatory response cell apoptosis blood-brain barrier cell structure protection |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.965661/full |
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