Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment
The 2019 novel coronavirus disease (COVID-19) has lasted for over 3 years and has seriously affected the regular life trajectory of human beings. The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has caused non-negligible harm to people’s respiratory systems and multiple organs. Altho...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-07-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897231184611 |
| _version_ | 1797788586686283776 |
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| author | Yuyin Fang Peizhen Lao Longqian Tang Jingyi Chen Yuxi Chen Lei Sun Wenwen Tan Xingliang Fan |
| author_facet | Yuyin Fang Peizhen Lao Longqian Tang Jingyi Chen Yuxi Chen Lei Sun Wenwen Tan Xingliang Fan |
| author_sort | Yuyin Fang |
| collection | DOAJ |
| description | The 2019 novel coronavirus disease (COVID-19) has lasted for over 3 years and has seriously affected the regular life trajectory of human beings. The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has caused non-negligible harm to people’s respiratory systems and multiple organs. Although the pathogenesis of COVID-19 has been fully elucidated, there is still a lack of effective and specific treatment for COVID-19. Mesenchymal stem cells (MSCs) or MSC-derived extracellular vesicles (MSC-EVs) by far have become the most promising candidates in preclinical studies and clinical trials, and MSC-related therapies have shown their potential to treat severe COVID-19. The multidirectional differentiation potential and immunomodulatory function of MSCs have allowed the cells to exert multiple cellular and molecular actions on different immune cells and organs. It is critical to understand the therapeutic roles of MSCs before entering the clinics for COVID-19 and other diseases. This review summarizes the recent progress of particular mechanisms underlying the immunomodulatory and tissue regenerative effects of MSCs toward COVID-19. We focused on discussing the functional roles of MSC-mediated effects on immune cell responses, cell survival, and organ regeneration. Besides, the novel discoveries and recent findings of MSC clinical application in patients with COVID-19 were highlighted. This will provide an overview of the current research on the rapid development of MSC-based therapies not only for COVID-19 but also for other immune-mediated/immune-dysregulating diseases. |
| first_indexed | 2024-03-13T01:37:41Z |
| format | Article |
| id | doaj.art-3f615ee67bdd4f59aa42494268c5b982 |
| institution | Directory Open Access Journal |
| issn | 1555-3892 |
| language | English |
| last_indexed | 2024-03-13T01:37:41Z |
| publishDate | 2023-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-3f615ee67bdd4f59aa42494268c5b9822023-07-03T19:33:58ZengSAGE PublishingCell Transplantation1555-38922023-07-013210.1177/09636897231184611Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 TreatmentYuyin Fang0Peizhen Lao1Longqian Tang2Jingyi Chen3Yuxi Chen4Lei Sun5Wenwen Tan6Xingliang Fan7Institute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaInstitute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaInstitute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaInstitute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaInstitute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaInstitute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaInstitute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaInstitute of Biological and Food Engineering, Guangdong University of Education, Guangzhou, P.R. ChinaThe 2019 novel coronavirus disease (COVID-19) has lasted for over 3 years and has seriously affected the regular life trajectory of human beings. The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has caused non-negligible harm to people’s respiratory systems and multiple organs. Although the pathogenesis of COVID-19 has been fully elucidated, there is still a lack of effective and specific treatment for COVID-19. Mesenchymal stem cells (MSCs) or MSC-derived extracellular vesicles (MSC-EVs) by far have become the most promising candidates in preclinical studies and clinical trials, and MSC-related therapies have shown their potential to treat severe COVID-19. The multidirectional differentiation potential and immunomodulatory function of MSCs have allowed the cells to exert multiple cellular and molecular actions on different immune cells and organs. It is critical to understand the therapeutic roles of MSCs before entering the clinics for COVID-19 and other diseases. This review summarizes the recent progress of particular mechanisms underlying the immunomodulatory and tissue regenerative effects of MSCs toward COVID-19. We focused on discussing the functional roles of MSC-mediated effects on immune cell responses, cell survival, and organ regeneration. Besides, the novel discoveries and recent findings of MSC clinical application in patients with COVID-19 were highlighted. This will provide an overview of the current research on the rapid development of MSC-based therapies not only for COVID-19 but also for other immune-mediated/immune-dysregulating diseases.https://doi.org/10.1177/09636897231184611 |
| spellingShingle | Yuyin Fang Peizhen Lao Longqian Tang Jingyi Chen Yuxi Chen Lei Sun Wenwen Tan Xingliang Fan Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment Cell Transplantation |
| title | Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment |
| title_full | Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment |
| title_fullStr | Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment |
| title_full_unstemmed | Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment |
| title_short | Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment |
| title_sort | mechanisms of potential therapeutic utilization of mesenchymal stem cells in covid 19 treatment |
| url | https://doi.org/10.1177/09636897231184611 |
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