Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage

Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage

C-type lectin Ocilrp2/Clec2i is widely expressed in dendritic cells, lymphokine-activated killer cells and activated T cells. Previous studies have shown that Ocilrp2 is an important regulator in the activation of T cells and NK cells. However, the role of Ocilrp2 in the inflammatory responses by ac...

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Bibliographic Details
Main Authors: Mingya Cao, Lina Ma, Chenyang Yan, Han Wang, Mengzhe Ran, Ying Chen, Xiao Wang, Xiaonan Liang, Lihui Chai, Xia Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Ocilrp2
TLR4
Syk
IL-6
macrophages
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.984520/full

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