Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis
Angiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid and lipoprotein trafficking and metabolism and is positively correlated with cardiovascular disease. Our objective was to evaluate the association between serum ANGPTL3 levels and endothelial function in patients on maintenance h...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/14/1/18 |
| _version_ | 1797343189937422336 |
|---|---|
| author | Tzu-Chiang Wu Bang-Gee Hsu Chiu-Huang Kuo Chih-Hsien Wang Jen-Pi Tsai |
| author_facet | Tzu-Chiang Wu Bang-Gee Hsu Chiu-Huang Kuo Chih-Hsien Wang Jen-Pi Tsai |
| author_sort | Tzu-Chiang Wu |
| collection | DOAJ |
| description | Angiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid and lipoprotein trafficking and metabolism and is positively correlated with cardiovascular disease. Our objective was to evaluate the association between serum ANGPTL3 levels and endothelial function in patients on maintenance hemodialysis (MHD). We enrolled 116 patients on MHD and obtained their blood test results from their medical records. Using a noninvasive digital thermal monitor, we determined the vascular reactivity index (VRI) as a measure of endothelial function. Serum ANGPTL3 concentration was measured by a commercial-enzyme-linked immunosorbent assay. Vascular reactivity was classified as poor in 17 (14.7%) patients, intermediate (1.0 ≤ VRI < 2.0) in 50 (43.1%) patients, and high (VRI ≥ 2.0) in 49 (42.2%) patients. Serum levels of ANGPTL3 (<i>p</i> < 0.001) and alkaline phosphatase (ALP, <i>p</i> = 0.025) increased significantly as the VRI decreased. The log-transformed serum ALP (log-ALP, <i>r</i> = −0.187, <i>p</i> = 0.045) and log-ANGPTL3 (<i>r</i> = −0.319, <i>p</i> < 0.001) showed a negative correlation with the VRI on univariate linear regression analysis. A significant negative correlation was found between log-ANGPTL3 and VRI (<i>p</i> < 0.001) on multivariate stepwise linear regression analysis. The findings of our investigation showed that, in patients with MHD, the ANGPTL3 concentration had a negative correlation with the VRI. |
| first_indexed | 2024-03-08T10:44:10Z |
| format | Article |
| id | doaj.art-3f628aafadc84f9283d7c4f0d8f4cfc2 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-08T10:44:10Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-3f628aafadc84f9283d7c4f0d8f4cfc22024-01-26T17:20:23ZengMDPI AGLife2075-17292023-12-011411810.3390/life14010018Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance HemodialysisTzu-Chiang Wu0Bang-Gee Hsu1Chiu-Huang Kuo2Chih-Hsien Wang3Jen-Pi Tsai4Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDepartment of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDepartment of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanDepartment of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, TaiwanSchool of Medicine, Tzu Chi University, Hualien 97004, TaiwanAngiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid and lipoprotein trafficking and metabolism and is positively correlated with cardiovascular disease. Our objective was to evaluate the association between serum ANGPTL3 levels and endothelial function in patients on maintenance hemodialysis (MHD). We enrolled 116 patients on MHD and obtained their blood test results from their medical records. Using a noninvasive digital thermal monitor, we determined the vascular reactivity index (VRI) as a measure of endothelial function. Serum ANGPTL3 concentration was measured by a commercial-enzyme-linked immunosorbent assay. Vascular reactivity was classified as poor in 17 (14.7%) patients, intermediate (1.0 ≤ VRI < 2.0) in 50 (43.1%) patients, and high (VRI ≥ 2.0) in 49 (42.2%) patients. Serum levels of ANGPTL3 (<i>p</i> < 0.001) and alkaline phosphatase (ALP, <i>p</i> = 0.025) increased significantly as the VRI decreased. The log-transformed serum ALP (log-ALP, <i>r</i> = −0.187, <i>p</i> = 0.045) and log-ANGPTL3 (<i>r</i> = −0.319, <i>p</i> < 0.001) showed a negative correlation with the VRI on univariate linear regression analysis. A significant negative correlation was found between log-ANGPTL3 and VRI (<i>p</i> < 0.001) on multivariate stepwise linear regression analysis. The findings of our investigation showed that, in patients with MHD, the ANGPTL3 concentration had a negative correlation with the VRI.https://www.mdpi.com/2075-1729/14/1/18endothelial functionangiopoietin-like protein 3hemodialysisdigital thermal monitoring testvascular reactivity index |
| spellingShingle | Tzu-Chiang Wu Bang-Gee Hsu Chiu-Huang Kuo Chih-Hsien Wang Jen-Pi Tsai Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis Life endothelial function angiopoietin-like protein 3 hemodialysis digital thermal monitoring test vascular reactivity index |
| title | Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis |
| title_full | Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis |
| title_fullStr | Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis |
| title_full_unstemmed | Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis |
| title_short | Serum Angiopoietin-like Protein 3 Levels Are Associated with Endothelial Function in Patients with Maintenance Hemodialysis |
| title_sort | serum angiopoietin like protein 3 levels are associated with endothelial function in patients with maintenance hemodialysis |
| topic | endothelial function angiopoietin-like protein 3 hemodialysis digital thermal monitoring test vascular reactivity index |
| url | https://www.mdpi.com/2075-1729/14/1/18 |
| work_keys_str_mv | AT tzuchiangwu serumangiopoietinlikeprotein3levelsareassociatedwithendothelialfunctioninpatientswithmaintenancehemodialysis AT banggeehsu serumangiopoietinlikeprotein3levelsareassociatedwithendothelialfunctioninpatientswithmaintenancehemodialysis AT chiuhuangkuo serumangiopoietinlikeprotein3levelsareassociatedwithendothelialfunctioninpatientswithmaintenancehemodialysis AT chihhsienwang serumangiopoietinlikeprotein3levelsareassociatedwithendothelialfunctioninpatientswithmaintenancehemodialysis AT jenpitsai serumangiopoietinlikeprotein3levelsareassociatedwithendothelialfunctioninpatientswithmaintenancehemodialysis |