Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees
In recent years, evidence has accumulated with regard to the ubiquity of pleiotropy across the genome, and shared genetic etiology is thought to play a large role in the widespread comorbidity among psychiatric disorders and risk factors. Recent methods investigate pleiotropy by estimating genetic c...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/10/1509 |
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| author | Floris Huider Yuri Milaneschi Matthijs D. van der Zee Eco J. C. de Geus Quinta Helmer Brenda W. J. H. Penninx Dorret I. Boomsma |
| author_facet | Floris Huider Yuri Milaneschi Matthijs D. van der Zee Eco J. C. de Geus Quinta Helmer Brenda W. J. H. Penninx Dorret I. Boomsma |
| author_sort | Floris Huider |
| collection | DOAJ |
| description | In recent years, evidence has accumulated with regard to the ubiquity of pleiotropy across the genome, and shared genetic etiology is thought to play a large role in the widespread comorbidity among psychiatric disorders and risk factors. Recent methods investigate pleiotropy by estimating genetic correlation from genome-wide association summary statistics. More comprehensive estimates can be derived from the known relatedness between genetic relatives. Analysis of extended twin pedigree data allows for the estimation of genetic correlation for additive and non-additive genetic effects, as well as a shared household effect. Here we conduct a series of bivariate genetic analyses in extended twin pedigree data on lifetime major depressive disorder (MDD) and three indicators of lifestyle, namely smoking behavior, physical inactivity, and obesity, decomposing phenotypic variance and covariance into genetic and environmental components. We analyze lifetime MDD and lifestyle data in a large multigenerational dataset of 19,496 individuals by variance component analysis in the ‘Mendel’ software. We find genetic correlations for MDD and smoking behavior (<i>r</i><sub>G</sub> = 0.249), physical inactivity (<i>r</i><sub>G</sub> = 0.161), body-mass index (<i>r</i><sub>G</sub> = 0.081), and obesity (<i>r</i><sub>G</sub> = 0.155), which were primarily driven by additive genetic effects. These outcomes provide evidence in favor of a shared genetic etiology between MDD and the lifestyle factors. |
| first_indexed | 2024-03-10T06:32:33Z |
| format | Article |
| id | doaj.art-3f629d5bba8c4328b57d295e83b67ec8 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T06:32:33Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-3f629d5bba8c4328b57d295e83b67ec82023-11-22T18:21:03ZengMDPI AGGenes2073-44252021-09-011210150910.3390/genes12101509Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin PedigreesFloris Huider0Yuri Milaneschi1Matthijs D. van der Zee2Eco J. C. de Geus3Quinta Helmer4Brenda W. J. H. Penninx5Dorret I. Boomsma6Department of Biological Psychology, Vrije Universiteit, 1081 BT Amsterdam, The NetherlandsAmsterdam Public Health (APH) Research Institute, Amsterdam, The NetherlandsDepartment of Biological Psychology, Vrije Universiteit, 1081 BT Amsterdam, The NetherlandsDepartment of Biological Psychology, Vrije Universiteit, 1081 BT Amsterdam, The NetherlandsDepartment of Biological Psychology, Vrije Universiteit, 1081 BT Amsterdam, The NetherlandsAmsterdam Public Health (APH) Research Institute, Amsterdam, The NetherlandsDepartment of Biological Psychology, Vrije Universiteit, 1081 BT Amsterdam, The NetherlandsIn recent years, evidence has accumulated with regard to the ubiquity of pleiotropy across the genome, and shared genetic etiology is thought to play a large role in the widespread comorbidity among psychiatric disorders and risk factors. Recent methods investigate pleiotropy by estimating genetic correlation from genome-wide association summary statistics. More comprehensive estimates can be derived from the known relatedness between genetic relatives. Analysis of extended twin pedigree data allows for the estimation of genetic correlation for additive and non-additive genetic effects, as well as a shared household effect. Here we conduct a series of bivariate genetic analyses in extended twin pedigree data on lifetime major depressive disorder (MDD) and three indicators of lifestyle, namely smoking behavior, physical inactivity, and obesity, decomposing phenotypic variance and covariance into genetic and environmental components. We analyze lifetime MDD and lifestyle data in a large multigenerational dataset of 19,496 individuals by variance component analysis in the ‘Mendel’ software. We find genetic correlations for MDD and smoking behavior (<i>r</i><sub>G</sub> = 0.249), physical inactivity (<i>r</i><sub>G</sub> = 0.161), body-mass index (<i>r</i><sub>G</sub> = 0.081), and obesity (<i>r</i><sub>G</sub> = 0.155), which were primarily driven by additive genetic effects. These outcomes provide evidence in favor of a shared genetic etiology between MDD and the lifestyle factors.https://www.mdpi.com/2073-4425/12/10/1509major depressive disorderlifestyleextended twin pedigreevariance decompositionMendelgenetic correlation |
| spellingShingle | Floris Huider Yuri Milaneschi Matthijs D. van der Zee Eco J. C. de Geus Quinta Helmer Brenda W. J. H. Penninx Dorret I. Boomsma Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees Genes major depressive disorder lifestyle extended twin pedigree variance decomposition Mendel genetic correlation |
| title | Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees |
| title_full | Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees |
| title_fullStr | Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees |
| title_full_unstemmed | Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees |
| title_short | Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees |
| title_sort | major depressive disorder and lifestyle correlated genetic effects in extended twin pedigrees |
| topic | major depressive disorder lifestyle extended twin pedigree variance decomposition Mendel genetic correlation |
| url | https://www.mdpi.com/2073-4425/12/10/1509 |
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