Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i>
Six new coumarin glycosides, genglycoside A–F (<b>1</b>–<b>6</b>), were isolated from the aerial parts of <i>Gendarussa vulgaris</i>, along with ten known analogues (<b>7</b>–<b>16</b>). Their structures were u...
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MDPI AG
2019-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/8/1456 |
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| author | Yanjun Sun Meiling Gao Haojie Chen Ruijie Han Hui Chen Kun Du Yanli Zhang Meng Li Yingying Si Weisheng Feng |
| author_facet | Yanjun Sun Meiling Gao Haojie Chen Ruijie Han Hui Chen Kun Du Yanli Zhang Meng Li Yingying Si Weisheng Feng |
| author_sort | Yanjun Sun |
| collection | DOAJ |
| description | Six new coumarin glycosides, genglycoside A–F (<b>1</b>–<b>6</b>), were isolated from the aerial parts of <i>Gendarussa vulgaris</i>, along with ten known analogues (<b>7</b>–<b>16</b>). Their structures were unambiguously established on the basis of extensive spectroscopic data and HPLC analysis. The cytotoxic activities of all isolated compounds were evaluated by MTT assay. Compound <b>12</b> showed the most potent cytotoxicity in Eca-109, MCF-7, and HepG2 cell lines. By the preliminary structure–activity relationships, it was firstly discovered that the glycosylation or esterification at 7,8-dihydroxy or 7-hydroxy drastically reduced the cytotoxic activity of the parent coumarin. |
| first_indexed | 2024-04-13T01:50:33Z |
| format | Article |
| id | doaj.art-3f62b454c4424ba5acfe72f816c41216 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T01:50:33Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3f62b454c4424ba5acfe72f816c412162022-12-22T03:07:53ZengMDPI AGMolecules1420-30492019-04-01248145610.3390/molecules24081456molecules24081456Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i>Yanjun Sun0Meiling Gao1Haojie Chen2Ruijie Han3Hui Chen4Kun Du5Yanli Zhang6Meng Li7Yingying Si8Weisheng Feng9Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, ChinaSix new coumarin glycosides, genglycoside A–F (<b>1</b>–<b>6</b>), were isolated from the aerial parts of <i>Gendarussa vulgaris</i>, along with ten known analogues (<b>7</b>–<b>16</b>). Their structures were unambiguously established on the basis of extensive spectroscopic data and HPLC analysis. The cytotoxic activities of all isolated compounds were evaluated by MTT assay. Compound <b>12</b> showed the most potent cytotoxicity in Eca-109, MCF-7, and HepG2 cell lines. By the preliminary structure–activity relationships, it was firstly discovered that the glycosylation or esterification at 7,8-dihydroxy or 7-hydroxy drastically reduced the cytotoxic activity of the parent coumarin.https://www.mdpi.com/1420-3049/24/8/1456<i>Gendarussa vulgaris</i>coumarin glycosidecytotoxic activity |
| spellingShingle | Yanjun Sun Meiling Gao Haojie Chen Ruijie Han Hui Chen Kun Du Yanli Zhang Meng Li Yingying Si Weisheng Feng Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i> Molecules <i>Gendarussa vulgaris</i> coumarin glycoside cytotoxic activity |
| title | Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i> |
| title_full | Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i> |
| title_fullStr | Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i> |
| title_full_unstemmed | Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i> |
| title_short | Six New Coumarin Glycosides from the Aerial Parts of <i>Gendarussa vulgaris</i> |
| title_sort | six new coumarin glycosides from the aerial parts of i gendarussa vulgaris i |
| topic | <i>Gendarussa vulgaris</i> coumarin glycoside cytotoxic activity |
| url | https://www.mdpi.com/1420-3049/24/8/1456 |
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