Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)?
ABSTRACT Mitoviruses in the family Mitoviridae are the mitochondria-replicating “naked RNA viruses” with genomes encoding only the replicase RNA-dependent RNA polymerase (RdRp) and prevalent across fungi, plants, and invertebrates. Arbuscular mycorrhizal fungi in the subphylum Glomeromycotina are ob...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2023-08-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mbio.00240-23 |
| _version_ | 1797730243068297216 |
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| author | Tatsuhiro Ezawa Alessandro Silvestri Hayato Maruyama Keitaro Tawaraya Mei Suzuki Yu Duan Massimo Turina Luisa Lanfranco |
| author_facet | Tatsuhiro Ezawa Alessandro Silvestri Hayato Maruyama Keitaro Tawaraya Mei Suzuki Yu Duan Massimo Turina Luisa Lanfranco |
| author_sort | Tatsuhiro Ezawa |
| collection | DOAJ |
| description | ABSTRACT Mitoviruses in the family Mitoviridae are the mitochondria-replicating “naked RNA viruses” with genomes encoding only the replicase RNA-dependent RNA polymerase (RdRp) and prevalent across fungi, plants, and invertebrates. Arbuscular mycorrhizal fungi in the subphylum Glomeromycotina are obligate plant symbionts that deliver water and nutrients to the host. We discovered distinct mitoviruses in glomeromycotinian fungi, namely “large duamitovirus,” encoding unusually large RdRp with a unique N-terminal motif that is endogenized in some host genomes. More than 400 viral sequences similar to the large duamitoviruses are present in metatranscriptome databases. They are globally distributed in soil ecosystems, consistent with the cosmopolitan distribution of glomeromycotinian fungi, and formed the most basal clade of the Mitoviridae in phylogenetic analysis. Given that glomeromycotinian fungi are the only confirmed hosts of these viruses, we propose the hypothesis that large duamitoviruses are the most ancestral lineage of the Mitoviridae that have been maintained exclusively in glomeromycotinian fungi. |
| first_indexed | 2024-03-12T11:41:27Z |
| format | Article |
| id | doaj.art-3f639e470dd04573bd4294c4986e58fc |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-03-12T11:41:27Z |
| publishDate | 2023-08-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-3f639e470dd04573bd4294c4986e58fc2023-08-31T15:04:21ZengAmerican Society for MicrobiologymBio2150-75112023-08-0114410.1128/mbio.00240-23Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)?Tatsuhiro Ezawa0Alessandro Silvestri1Hayato Maruyama2Keitaro Tawaraya3Mei Suzuki4Yu Duan5Massimo Turina6Luisa Lanfranco7Graduate School of Agriculture, Hokkaido University , Sapporo, JapanDepartment of Life Sciences and Systems Biology, University of Torino , Torino, ItalyGraduate School of Agriculture, Hokkaido University , Sapporo, JapanFaculty of Agriculture, Yamagata University , Tsuruoka, JapanGraduate School of Agriculture, Hokkaido University , Sapporo, JapanGraduate School of Agriculture, Hokkaido University , Sapporo, JapanInstitute for Sustainable Plant Protection–CNR Torino , Torino, ItalyDepartment of Life Sciences and Systems Biology, University of Torino , Torino, ItalyABSTRACT Mitoviruses in the family Mitoviridae are the mitochondria-replicating “naked RNA viruses” with genomes encoding only the replicase RNA-dependent RNA polymerase (RdRp) and prevalent across fungi, plants, and invertebrates. Arbuscular mycorrhizal fungi in the subphylum Glomeromycotina are obligate plant symbionts that deliver water and nutrients to the host. We discovered distinct mitoviruses in glomeromycotinian fungi, namely “large duamitovirus,” encoding unusually large RdRp with a unique N-terminal motif that is endogenized in some host genomes. More than 400 viral sequences similar to the large duamitoviruses are present in metatranscriptome databases. They are globally distributed in soil ecosystems, consistent with the cosmopolitan distribution of glomeromycotinian fungi, and formed the most basal clade of the Mitoviridae in phylogenetic analysis. Given that glomeromycotinian fungi are the only confirmed hosts of these viruses, we propose the hypothesis that large duamitoviruses are the most ancestral lineage of the Mitoviridae that have been maintained exclusively in glomeromycotinian fungi.https://journals.asm.org/doi/10.1128/mbio.00240-23mycovirusesmycorrhizaeMitoviridaeGlomeromycotinaevolutionplus-strand RNA virus |
| spellingShingle | Tatsuhiro Ezawa Alessandro Silvestri Hayato Maruyama Keitaro Tawaraya Mei Suzuki Yu Duan Massimo Turina Luisa Lanfranco Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)? mBio mycoviruses mycorrhizae Mitoviridae Glomeromycotina evolution plus-strand RNA virus |
| title | Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)? |
| title_full | Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)? |
| title_fullStr | Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)? |
| title_full_unstemmed | Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)? |
| title_short | Structurally distinct mitoviruses: are they an ancestral lineage of the Mitoviridae exclusive to arbuscular mycorrhizal fungi (Glomeromycotina)? |
| title_sort | structurally distinct mitoviruses are they an ancestral lineage of the mitoviridae exclusive to arbuscular mycorrhizal fungi glomeromycotina |
| topic | mycoviruses mycorrhizae Mitoviridae Glomeromycotina evolution plus-strand RNA virus |
| url | https://journals.asm.org/doi/10.1128/mbio.00240-23 |
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