Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome
The importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. This re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/22/7727 |
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| author | Gael N. N. Neba Ambe Carlo Breda Avninder Singh Bhambra Randolph R. J. Arroo |
| author_facet | Gael N. N. Neba Ambe Carlo Breda Avninder Singh Bhambra Randolph R. J. Arroo |
| author_sort | Gael N. N. Neba Ambe |
| collection | DOAJ |
| description | The importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. This review highlights a number of dietary compounds that positively affect the maintenance of the circadian clock. Notably the polymethoxyflavone nobiletin has shown some encouraging results in pre-clinical experiments. Although many more experiments are needed to fully elucidate its exact mechanism of action, it is a promising candidate with potential as a chronotherapeutic agent. |
| first_indexed | 2024-03-09T18:07:46Z |
| format | Article |
| id | doaj.art-3f63e46302b34e018dd3d3fa6b42a0f0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:07:46Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3f63e46302b34e018dd3d3fa6b42a0f02023-11-24T09:20:08ZengMDPI AGMolecules1420-30492022-11-012722772710.3390/molecules27227727Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic SyndromeGael N. N. Neba Ambe0Carlo Breda1Avninder Singh Bhambra2Randolph R. J. Arroo3Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UKSchool of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UKSchool of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UKLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UKThe importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. This review highlights a number of dietary compounds that positively affect the maintenance of the circadian clock. Notably the polymethoxyflavone nobiletin has shown some encouraging results in pre-clinical experiments. Although many more experiments are needed to fully elucidate its exact mechanism of action, it is a promising candidate with potential as a chronotherapeutic agent.https://www.mdpi.com/1420-3049/27/22/7727polymethoxy flavoneageingnon-communicable diseaseschemoprevention |
| spellingShingle | Gael N. N. Neba Ambe Carlo Breda Avninder Singh Bhambra Randolph R. J. Arroo Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome Molecules polymethoxy flavone ageing non-communicable diseases chemoprevention |
| title | Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome |
| title_full | Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome |
| title_fullStr | Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome |
| title_full_unstemmed | Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome |
| title_short | Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome |
| title_sort | effect of the citrus flavone nobiletin on circadian rhythms and metabolic syndrome |
| topic | polymethoxy flavone ageing non-communicable diseases chemoprevention |
| url | https://www.mdpi.com/1420-3049/27/22/7727 |
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