Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics?
Oxidative stress (OS) is a major disruption in the physiology of the lacrimal functional unit (LFU). Antioxidant enzymes have dual protective activities: antioxidant and antimicrobial activities. Peroxidases have been indistinctly used as markers of the secretory activity of the LFU and implicated i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.824726/full |
| _version_ | 1818319068154822656 |
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| author | Camila Nunes Lemos Lilian Eslaine Costa Mendes da Silva Jacqueline Ferreira Faustino Marina Zilio Fantucci Adriana de Andrade Batista Murashima Leidiane Adriano Monica Alves Eduardo Melani Rocha |
| author_facet | Camila Nunes Lemos Lilian Eslaine Costa Mendes da Silva Jacqueline Ferreira Faustino Marina Zilio Fantucci Adriana de Andrade Batista Murashima Leidiane Adriano Monica Alves Eduardo Melani Rocha |
| author_sort | Camila Nunes Lemos |
| collection | DOAJ |
| description | Oxidative stress (OS) is a major disruption in the physiology of the lacrimal functional unit (LFU). Antioxidant enzymes have dual protective activities: antioxidant and antimicrobial activities. Peroxidases have been indistinctly used as markers of the secretory activity of the LFU and implicated in the pathophysiology, diagnosis and treatment of dry eye disease (DED), even though they comprise a large family of enzymes that includes lactoperoxidase (LPO) and glutathione peroxidase (GPO), among others. Assays to measure and correlate OS with other local LFU phenomena have methodological limitations. Studies implicate molecules and reactions involved in OS as markers of homeostasis, and other studies identify them as part of the physiopathology of diseases. Despite these conflicting concepts and observations, it is clear that OS is influential in the development of DED. Moreover, many antioxidant strategies have been proposed for its treatment, including calorie restriction to nutritional supplementation. This review offers a critical analysis of the biological mechanisms, diagnostic outcomes, drug use, dietary supplements, and life habits that implicate the influence of OS on DED. |
| first_indexed | 2024-12-13T10:03:14Z |
| format | Article |
| id | doaj.art-3f651778da2b46828eb1bb8e3198304f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T10:03:14Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-3f651778da2b46828eb1bb8e3198304f2022-12-21T23:51:35ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-03-011010.3389/fcell.2022.824726824726Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics?Camila Nunes Lemos0Lilian Eslaine Costa Mendes da Silva1Jacqueline Ferreira Faustino2Marina Zilio Fantucci3Adriana de Andrade Batista Murashima4Leidiane Adriano5Monica Alves6Eduardo Melani Rocha7Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Ophthalmology and Otorhinolaryngology, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, BrazilDepartment of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilOxidative stress (OS) is a major disruption in the physiology of the lacrimal functional unit (LFU). Antioxidant enzymes have dual protective activities: antioxidant and antimicrobial activities. Peroxidases have been indistinctly used as markers of the secretory activity of the LFU and implicated in the pathophysiology, diagnosis and treatment of dry eye disease (DED), even though they comprise a large family of enzymes that includes lactoperoxidase (LPO) and glutathione peroxidase (GPO), among others. Assays to measure and correlate OS with other local LFU phenomena have methodological limitations. Studies implicate molecules and reactions involved in OS as markers of homeostasis, and other studies identify them as part of the physiopathology of diseases. Despite these conflicting concepts and observations, it is clear that OS is influential in the development of DED. Moreover, many antioxidant strategies have been proposed for its treatment, including calorie restriction to nutritional supplementation. This review offers a critical analysis of the biological mechanisms, diagnostic outcomes, drug use, dietary supplements, and life habits that implicate the influence of OS on DED.https://www.frontiersin.org/articles/10.3389/fcell.2022.824726/fulllacrimal glandocular surfaceoxidative stresdry eyelacrimal functional unit (LFU) |
| spellingShingle | Camila Nunes Lemos Lilian Eslaine Costa Mendes da Silva Jacqueline Ferreira Faustino Marina Zilio Fantucci Adriana de Andrade Batista Murashima Leidiane Adriano Monica Alves Eduardo Melani Rocha Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics? Frontiers in Cell and Developmental Biology lacrimal gland ocular surface oxidative stres dry eye lacrimal functional unit (LFU) |
| title | Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics? |
| title_full | Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics? |
| title_fullStr | Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics? |
| title_full_unstemmed | Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics? |
| title_short | Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics? |
| title_sort | oxidative stress in the protection and injury of the lacrimal gland and the ocular surface are there perspectives for therapeutics |
| topic | lacrimal gland ocular surface oxidative stres dry eye lacrimal functional unit (LFU) |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.824726/full |
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