Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
“Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07638-4 |
| _version_ | 1830209754810548224 |
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| author | Kuo Zhang Yuying Zhang Lijie Gu Miaomiao Lan Chuncheng Liu Meng Wang Yang Su Mengxu Ge Tongtong Wang Yingying Yu Chang Liu Lei Li Qiuyan Li Yaofeng Zhao Zhengquan Yu Fudi Wang Ning Li Qingyong Meng |
| author_facet | Kuo Zhang Yuying Zhang Lijie Gu Miaomiao Lan Chuncheng Liu Meng Wang Yang Su Mengxu Ge Tongtong Wang Yingying Yu Chang Liu Lei Li Qiuyan Li Yaofeng Zhao Zhengquan Yu Fudi Wang Ning Li Qingyong Meng |
| author_sort | Kuo Zhang |
| collection | DOAJ |
| description | “Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy. |
| first_indexed | 2024-12-18T05:13:39Z |
| format | Article |
| id | doaj.art-3f654eba92714c41bb88ea27854f0718 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:13:39Z |
| publishDate | 2018-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3f654eba92714c41bb88ea27854f07182022-12-21T21:19:48ZengNature PortfolioNature Communications2041-17232018-12-019111610.1038/s41467-018-07638-4Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagyKuo Zhang0Yuying Zhang1Lijie Gu2Miaomiao Lan3Chuncheng Liu4Meng Wang5Yang Su6Mengxu Ge7Tongtong Wang8Yingying Yu9Chang Liu10Lei LiQiuyan Li11Yaofeng Zhao12Zhengquan Yu13Fudi Wang14Ning Li15Qingyong Meng16State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural UniversityState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University“Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy.https://doi.org/10.1038/s41467-018-07638-4 |
| spellingShingle | Kuo Zhang Yuying Zhang Lijie Gu Miaomiao Lan Chuncheng Liu Meng Wang Yang Su Mengxu Ge Tongtong Wang Yingying Yu Chang Liu Lei Li Qiuyan Li Yaofeng Zhao Zhengquan Yu Fudi Wang Ning Li Qingyong Meng Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy Nature Communications |
| title | Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy |
| title_full | Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy |
| title_fullStr | Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy |
| title_full_unstemmed | Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy |
| title_short | Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy |
| title_sort | islr regulates canonical wnt signaling mediated skeletal muscle regeneration by stabilizing dishevelled 2 and preventing autophagy |
| url | https://doi.org/10.1038/s41467-018-07638-4 |
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