Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder
Background: An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396417302487 |
| _version_ | 1818313726892179456 |
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| author | Youjin Zhao Lizhou Chen Wenjing Zhang Yuan Xiao Chandan Shah Hongru Zhu Minlan Yuan Huaiqiang Sun Qiang Yue Zhiyun Jia Wei Zhang Weihong Kuang Qiyong Gong Su Lui |
| author_facet | Youjin Zhao Lizhou Chen Wenjing Zhang Yuan Xiao Chandan Shah Hongru Zhu Minlan Yuan Huaiqiang Sun Qiang Yue Zhiyun Jia Wei Zhang Weihong Kuang Qiyong Gong Su Lui |
| author_sort | Youjin Zhao |
| collection | DOAJ |
| description | Background: An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess the gray matter volume (GMV) and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients.
Methods: High-resolution T1-weighted images were acquired from 37 non-comorbid MDD patients, 24 non-comorbid SAD patients and 41 healthy controls (HCs). Voxel-based morphometry analysis of the GMV (corrected with a false discovery rate of p < 0.001) and vertex-based analysis of cortical thickness (corrected with a clusterwise probability of p < 0.001) were performed, and group differences were compared by ANOVA followed by post hoc tests.
Outcomes: Relative to the HCs, both the MDD patients and SAD patients showed the following results: GMV reductions in the bilateral orbital frontal cortex (OFC), putamen, and thalamus; cortical thickening in the bilateral medial prefrontal cortex, posterior dorsolateral prefrontal cortex, insular cortex, left temporal pole, and right superior parietal cortex; and cortical thinning in the left lateral OFC and bilateral rostral middle frontal cortex. In addition, MDD patients specifically showed a greater thickness in the left fusiform gyrus and right lateral occipital cortex and a thinner thickness in the bilateral lingual and left cuneus. SAD patients specifically showed a thinner cortical thickness in the right precentral cortex.
Interpretation: Our results indicate that MDD and SAD share common patterns of gray matter abnormalities in the orbitofrontal-striatal-thalamic circuit, salience network and dorsal attention network. These consistent structural differences in the two patient groups may contribute to the broad spectrum of emotional, cognitive and behavioral disturbances observed in MDD patients and SAD patients. In addition, we found disorder-specific involvement of the visual processing regions in MDD and the precentral cortex in SAD. These findings provide new evidence regarding the shared and specific neuropathological mechanisms that underlie MDD and SAD. |
| first_indexed | 2024-12-13T08:38:20Z |
| format | Article |
| id | doaj.art-3f656bf440444850936f46236932d3f2 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-13T08:38:20Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-3f656bf440444850936f46236932d3f22022-12-21T23:53:36ZengElsevierEBioMedicine2352-39642017-07-0121C22823510.1016/j.ebiom.2017.06.013Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety DisorderYoujin Zhao0Lizhou Chen1Wenjing Zhang2Yuan Xiao3Chandan Shah4Hongru Zhu5Minlan Yuan6Huaiqiang Sun7Qiang Yue8Zhiyun Jia9Wei Zhang10Weihong Kuang11Qiyong Gong12Su Lui13Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaMental Health Center, West China Hospital of Sichuan University, Chengdu, PR ChinaMental Health Center, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaMental Health Center, West China Hospital of Sichuan University, Chengdu, PR ChinaMental Health Center, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, PR ChinaBackground: An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess the gray matter volume (GMV) and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients. Methods: High-resolution T1-weighted images were acquired from 37 non-comorbid MDD patients, 24 non-comorbid SAD patients and 41 healthy controls (HCs). Voxel-based morphometry analysis of the GMV (corrected with a false discovery rate of p < 0.001) and vertex-based analysis of cortical thickness (corrected with a clusterwise probability of p < 0.001) were performed, and group differences were compared by ANOVA followed by post hoc tests. Outcomes: Relative to the HCs, both the MDD patients and SAD patients showed the following results: GMV reductions in the bilateral orbital frontal cortex (OFC), putamen, and thalamus; cortical thickening in the bilateral medial prefrontal cortex, posterior dorsolateral prefrontal cortex, insular cortex, left temporal pole, and right superior parietal cortex; and cortical thinning in the left lateral OFC and bilateral rostral middle frontal cortex. In addition, MDD patients specifically showed a greater thickness in the left fusiform gyrus and right lateral occipital cortex and a thinner thickness in the bilateral lingual and left cuneus. SAD patients specifically showed a thinner cortical thickness in the right precentral cortex. Interpretation: Our results indicate that MDD and SAD share common patterns of gray matter abnormalities in the orbitofrontal-striatal-thalamic circuit, salience network and dorsal attention network. These consistent structural differences in the two patient groups may contribute to the broad spectrum of emotional, cognitive and behavioral disturbances observed in MDD patients and SAD patients. In addition, we found disorder-specific involvement of the visual processing regions in MDD and the precentral cortex in SAD. These findings provide new evidence regarding the shared and specific neuropathological mechanisms that underlie MDD and SAD.http://www.sciencedirect.com/science/article/pii/S2352396417302487Major depressive disorder (MDD)Social anxiety disorder (SAD)Voxel-based morphometry (VBM)Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL)Gray matter volume (GMV)Cortical thickness |
| spellingShingle | Youjin Zhao Lizhou Chen Wenjing Zhang Yuan Xiao Chandan Shah Hongru Zhu Minlan Yuan Huaiqiang Sun Qiang Yue Zhiyun Jia Wei Zhang Weihong Kuang Qiyong Gong Su Lui Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder EBioMedicine Major depressive disorder (MDD) Social anxiety disorder (SAD) Voxel-based morphometry (VBM) Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) Gray matter volume (GMV) Cortical thickness |
| title | Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder |
| title_full | Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder |
| title_fullStr | Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder |
| title_full_unstemmed | Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder |
| title_short | Gray Matter Abnormalities in Non-comorbid Medication-naive Patients with Major Depressive Disorder or Social Anxiety Disorder |
| title_sort | gray matter abnormalities in non comorbid medication naive patients with major depressive disorder or social anxiety disorder |
| topic | Major depressive disorder (MDD) Social anxiety disorder (SAD) Voxel-based morphometry (VBM) Diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) Gray matter volume (GMV) Cortical thickness |
| url | http://www.sciencedirect.com/science/article/pii/S2352396417302487 |
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