Pleiotropic effects of ursodeoxycholic acid
The article summarizes the literature data on the expansion of the range of application of ursodeoxycholic acid due to its various mechanisms of action. Almost 50-year history of the study of its properties has proven choleretic, litholytic, antiapoptotic, anti-inflammatory, immunomodulatory, cytopr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2021-06-01
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| Series: | Gastroenterologìa |
| Subjects: | |
| Online Access: | http://gastro.zaslavsky.com.ua/article/view/233637 |
| _version_ | 1828144458089103360 |
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| author | Yu.М. Stepanov А.V. Salenko |
| author_facet | Yu.М. Stepanov А.V. Salenko |
| author_sort | Yu.М. Stepanov |
| collection | DOAJ |
| description | The article summarizes the literature data on the expansion of the range of application of ursodeoxycholic acid due to its various mechanisms of action. Almost 50-year history of the study of its properties has proven choleretic, litholytic, antiapoptotic, anti-inflammatory, immunomodulatory, cytoprotective, antifibrotic and hypocholesterolemic effects. In addition to the well-known functions of bile acids, their role has been shown as signaling, endocrine molecules that regulate glucose, lipids, and energy metabolism through pathways mediated by the activation of the nuclear receptor of the farnesoid X receptor and the cell surface G protein-coupled receptor, TGR5. The variety of nosological forms in which this substance can be successfully used is substantiated. |
| first_indexed | 2024-04-11T20:15:44Z |
| format | Article |
| id | doaj.art-3f67b58e4a51440b8a82c85705ec7291 |
| institution | Directory Open Access Journal |
| issn | 2308-2097 2518-7880 |
| language | English |
| last_indexed | 2024-04-11T20:15:44Z |
| publishDate | 2021-06-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Gastroenterologìa |
| spelling | doaj.art-3f67b58e4a51440b8a82c85705ec72912022-12-22T04:04:59ZengZaslavsky O.Yu.Gastroenterologìa2308-20972518-78802021-06-0155211512110.22141/2308-2097.55.2.2021.233637271275Pleiotropic effects of ursodeoxycholic acidYu.М. Stepanov0https://orcid.org/0000-0002-6721-2468А.V. Salenko1https://orcid.org/0000-0001-7692-7118State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, UkraineDnipro State Medical University, Dnipro, UkraineThe article summarizes the literature data on the expansion of the range of application of ursodeoxycholic acid due to its various mechanisms of action. Almost 50-year history of the study of its properties has proven choleretic, litholytic, antiapoptotic, anti-inflammatory, immunomodulatory, cytoprotective, antifibrotic and hypocholesterolemic effects. In addition to the well-known functions of bile acids, their role has been shown as signaling, endocrine molecules that regulate glucose, lipids, and energy metabolism through pathways mediated by the activation of the nuclear receptor of the farnesoid X receptor and the cell surface G protein-coupled receptor, TGR5. The variety of nosological forms in which this substance can be successfully used is substantiated.http://gastro.zaslavsky.com.ua/article/view/233637ursodeoxycholic acid, properties, mechanism of action, farnesoid x receptor, tgr5 |
| spellingShingle | Yu.М. Stepanov А.V. Salenko Pleiotropic effects of ursodeoxycholic acid Gastroenterologìa ursodeoxycholic acid, properties, mechanism of action, farnesoid x receptor, tgr5 |
| title | Pleiotropic effects of ursodeoxycholic acid |
| title_full | Pleiotropic effects of ursodeoxycholic acid |
| title_fullStr | Pleiotropic effects of ursodeoxycholic acid |
| title_full_unstemmed | Pleiotropic effects of ursodeoxycholic acid |
| title_short | Pleiotropic effects of ursodeoxycholic acid |
| title_sort | pleiotropic effects of ursodeoxycholic acid |
| topic | ursodeoxycholic acid, properties, mechanism of action, farnesoid x receptor, tgr5 |
| url | http://gastro.zaslavsky.com.ua/article/view/233637 |
| work_keys_str_mv | AT yumstepanov pleiotropiceffectsofursodeoxycholicacid AT avsalenko pleiotropiceffectsofursodeoxycholicacid |