Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons
Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expres...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/10/11/186 |
| _version_ | 1797547261746479104 |
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| author | Maliana El Aamri Ghita Yammouri Hasna Mohammadi Aziz Amine Hafsa Korri-Youssoufi |
| author_facet | Maliana El Aamri Ghita Yammouri Hasna Mohammadi Aziz Amine Hafsa Korri-Youssoufi |
| author_sort | Maliana El Aamri |
| collection | DOAJ |
| description | Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expression level in body fluid is strongly correlated to cancer. Various biosensors involving the detection of miRNA for cancer diagnosis were developed. The present review offers a comprehensive overview of the recent developments in electrochemical biosensor for miRNA cancer marker detection from 2015 to 2020. The review focuses on the approaches to direct miRNA detection based on the electrochemical signal. It includes a RedOx-labeled probe with different designs, RedOx DNA-intercalating agents, various kinds of RedOx catalysts used to produce a signal response, and finally a free RedOx indicator. Furthermore, the advantages and drawbacks of these approaches are highlighted. |
| first_indexed | 2024-03-10T14:41:48Z |
| format | Article |
| id | doaj.art-3f687ed0fe8c4979a8862d9ac0206f63 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T14:41:48Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-3f687ed0fe8c4979a8862d9ac0206f632023-11-20T21:43:23ZengMDPI AGBiosensors2079-63742020-11-01101118610.3390/bios10110186Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and ConsMaliana El Aamri0Ghita Yammouri1Hasna Mohammadi2Aziz Amine3Hafsa Korri-Youssoufi4Laboratory of Process Engineering & Environment, Faculty of Sciences and Techniques, Hassan II, University of Casablanca, B.P.146, Mohammedia 28806, MoroccoLaboratory of Process Engineering & Environment, Faculty of Sciences and Techniques, Hassan II, University of Casablanca, B.P.146, Mohammedia 28806, MoroccoLaboratory of Process Engineering & Environment, Faculty of Sciences and Techniques, Hassan II, University of Casablanca, B.P.146, Mohammedia 28806, MoroccoLaboratory of Process Engineering & Environment, Faculty of Sciences and Techniques, Hassan II, University of Casablanca, B.P.146, Mohammedia 28806, MoroccoUniversité Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Equipe de Chimie Biorganique et Bioinorganique (ECBB), Bât 420, 2 Rue du Doyen Georges Poitou, 91400 Orsay, FranceCancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection. MicroRNA (miRNA) is an RNA cancer biomarker where the expression level in body fluid is strongly correlated to cancer. Various biosensors involving the detection of miRNA for cancer diagnosis were developed. The present review offers a comprehensive overview of the recent developments in electrochemical biosensor for miRNA cancer marker detection from 2015 to 2020. The review focuses on the approaches to direct miRNA detection based on the electrochemical signal. It includes a RedOx-labeled probe with different designs, RedOx DNA-intercalating agents, various kinds of RedOx catalysts used to produce a signal response, and finally a free RedOx indicator. Furthermore, the advantages and drawbacks of these approaches are highlighted.https://www.mdpi.com/2079-6374/10/11/186microRNAelectrochemical biosensorcatalystsRedOx indicatorcancer biomarker |
| spellingShingle | Maliana El Aamri Ghita Yammouri Hasna Mohammadi Aziz Amine Hafsa Korri-Youssoufi Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons Biosensors microRNA electrochemical biosensor catalysts RedOx indicator cancer biomarker |
| title | Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons |
| title_full | Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons |
| title_fullStr | Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons |
| title_full_unstemmed | Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons |
| title_short | Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons |
| title_sort | electrochemical biosensors for detection of microrna as a cancer biomarker pros and cons |
| topic | microRNA electrochemical biosensor catalysts RedOx indicator cancer biomarker |
| url | https://www.mdpi.com/2079-6374/10/11/186 |
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