Overexpression of the Bacteriophage T4 <i>motB</i> Gene Alters H-NS Dependent Repression of Specific Host DNA

Overexpression of the Bacteriophage T4 <i>motB</i> Gene Alters H-NS Dependent Repression of Specific Host DNA

The bacteriophage T4 early gene product MotB binds tightly but nonspecifically to DNA, copurifies with the host Nucleoid Associated Protein (NAP) H-NS in the presence of DNA and improves T4 fitness. However, the T4 transcriptome is not significantly affected by a <i>motB</i> knockdown. H...

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Bibliographic Details
Main Authors: Jennifer Patterson-West, Chin-Hsien Tai, Bokyung Son, Meng-Lun Hsieh, James R. Iben, Deborah M. Hinton
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
bacteriophage T4
MotB
H-NS
nucleoid
host takeover
DNA-binding protein
Online Access:https://www.mdpi.com/1999-4915/13/1/84

Internet

https://www.mdpi.com/1999-4915/13/1/84

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