Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery
The aim of our present study is to evaluate the efficacy of pranoprofen eye drops as pain relief during sequential second-eye cataract surgery and to investigate the possible mechanism. Seventy-six patients scheduled for bilateral sequential cataract surgery were randomly assigned to two groups: (1)...
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.00783/full |
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| author | Yinglei Zhang Yinglei Zhang Yinglei Zhang Yinglei Zhang Yu Du Yu Du Yu Du Yu Du Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Xiangjia Zhu Xiangjia Zhu Xiangjia Zhu Xiangjia Zhu Yi Lu Yi Lu Yi Lu Yi Lu |
| author_facet | Yinglei Zhang Yinglei Zhang Yinglei Zhang Yinglei Zhang Yu Du Yu Du Yu Du Yu Du Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Xiangjia Zhu Xiangjia Zhu Xiangjia Zhu Xiangjia Zhu Yi Lu Yi Lu Yi Lu Yi Lu |
| author_sort | Yinglei Zhang |
| collection | DOAJ |
| description | The aim of our present study is to evaluate the efficacy of pranoprofen eye drops as pain relief during sequential second-eye cataract surgery and to investigate the possible mechanism. Seventy-six patients scheduled for bilateral sequential cataract surgery were randomly assigned to two groups: (1) treatment group (administered pranoprofen eye drops), or (2) control group (administered artificial tears). Preoperative anxiety and intraoperative pain were assessed. Monocyte chemoattractant protein 1 (MCP-1) in the aqueous humor was measured with a suspension cytokine array. An extracapsular lens extraction model was established in the Wistar rat and the MCP-1 concentrations were measured with an enzyme-linked immunosorbent assay. We found that in the control group, the pain scores were significantly higher during second-eye surgery than during first-eye surgery (both scores P < 0.001). In the treatment group, there was no significant difference in the pain scores during first-eye and second-eye surgery (both scores P > 0.1). The pain during second-eye surgery was significantly lower in the treatment group than in the control group (both scores P < 0.01). And in the 1-week and 6-week interval subgroups, the pain scores during second-eye surgery were significantly lower in the treatment group than the control group (P = 0.047 and P = 0.035, respectively). While the second-eye MCP-1 level was significantly lower after a 1-week interval in the treatment group than in the control group (P = 0.012), but did not differ significantly after a 6-week interval (P > 0.1). A parallel trend in the MCP-1 concentration was detected in the rat model. In conclusion, the preoperative administration of pranoprofen eye drops reduced the perceived pain during second-eye cataract surgery, especially when performed after 1-week and 6-week intervals between the first-eye and second-eye surgery. MCP-1, a pain-related cytokine, was associated with the pain-relief mechanism of pranoprofen when second-eye surgery was performed 1 week after second-eye surgery. |
| first_indexed | 2024-12-22T16:56:25Z |
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| language | English |
| last_indexed | 2024-12-22T16:56:25Z |
| publishDate | 2018-07-01 |
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| spelling | doaj.art-3f68e49c9c024749a523e897ec62e00e2022-12-21T18:19:26ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-07-01910.3389/fphar.2018.00783374424Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract SurgeryYinglei Zhang0Yinglei Zhang1Yinglei Zhang2Yinglei Zhang3Yu Du4Yu Du5Yu Du6Yu Du7Yongxiang Jiang8Yongxiang Jiang9Yongxiang Jiang10Yongxiang Jiang11Xiangjia Zhu12Xiangjia Zhu13Xiangjia Zhu14Xiangjia Zhu15Yi Lu16Yi Lu17Yi Lu18Yi Lu19Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaEye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaKey Laboratory of Myopia, Ministry of Health, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaEye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaKey Laboratory of Myopia, Ministry of Health, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaEye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaKey Laboratory of Myopia, Ministry of Health, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaEye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaKey Laboratory of Myopia, Ministry of Health, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaEye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, ChinaKey Laboratory of Myopia, Ministry of Health, Shanghai, ChinaShanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, ChinaThe aim of our present study is to evaluate the efficacy of pranoprofen eye drops as pain relief during sequential second-eye cataract surgery and to investigate the possible mechanism. Seventy-six patients scheduled for bilateral sequential cataract surgery were randomly assigned to two groups: (1) treatment group (administered pranoprofen eye drops), or (2) control group (administered artificial tears). Preoperative anxiety and intraoperative pain were assessed. Monocyte chemoattractant protein 1 (MCP-1) in the aqueous humor was measured with a suspension cytokine array. An extracapsular lens extraction model was established in the Wistar rat and the MCP-1 concentrations were measured with an enzyme-linked immunosorbent assay. We found that in the control group, the pain scores were significantly higher during second-eye surgery than during first-eye surgery (both scores P < 0.001). In the treatment group, there was no significant difference in the pain scores during first-eye and second-eye surgery (both scores P > 0.1). The pain during second-eye surgery was significantly lower in the treatment group than in the control group (both scores P < 0.01). And in the 1-week and 6-week interval subgroups, the pain scores during second-eye surgery were significantly lower in the treatment group than the control group (P = 0.047 and P = 0.035, respectively). While the second-eye MCP-1 level was significantly lower after a 1-week interval in the treatment group than in the control group (P = 0.012), but did not differ significantly after a 6-week interval (P > 0.1). A parallel trend in the MCP-1 concentration was detected in the rat model. In conclusion, the preoperative administration of pranoprofen eye drops reduced the perceived pain during second-eye cataract surgery, especially when performed after 1-week and 6-week intervals between the first-eye and second-eye surgery. MCP-1, a pain-related cytokine, was associated with the pain-relief mechanism of pranoprofen when second-eye surgery was performed 1 week after second-eye surgery.https://www.frontiersin.org/article/10.3389/fphar.2018.00783/fullcataract surgerypainpranoprofenMCP-1ECLE rat model |
| spellingShingle | Yinglei Zhang Yinglei Zhang Yinglei Zhang Yinglei Zhang Yu Du Yu Du Yu Du Yu Du Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Yongxiang Jiang Xiangjia Zhu Xiangjia Zhu Xiangjia Zhu Xiangjia Zhu Yi Lu Yi Lu Yi Lu Yi Lu Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery Frontiers in Pharmacology cataract surgery pain pranoprofen MCP-1 ECLE rat model |
| title | Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery |
| title_full | Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery |
| title_fullStr | Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery |
| title_full_unstemmed | Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery |
| title_short | Effects of Pranoprofen on Aqueous Humor Monocyte Chemoattractant Protein-1 Level and Pain Relief During Second-Eye Cataract Surgery |
| title_sort | effects of pranoprofen on aqueous humor monocyte chemoattractant protein 1 level and pain relief during second eye cataract surgery |
| topic | cataract surgery pain pranoprofen MCP-1 ECLE rat model |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.00783/full |
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