Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached Grafts
<i>Background and Objectives:</i> To assess the correlation between the degree of target coronary artery stenosis measured by instantaneous wave-free ratio (iFR) and the intraoperative transit time flow measurement (TTFM) of attached grafts as well as evaluate flow competition between th...
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MDPI AG
2020-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/12/714 |
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| author | Almas Tolegenuly Rasa Ordiene Arslan Mamedov Ramunas Unikas Rimantas Benetis |
| author_facet | Almas Tolegenuly Rasa Ordiene Arslan Mamedov Ramunas Unikas Rimantas Benetis |
| author_sort | Almas Tolegenuly |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> To assess the correlation between the degree of target coronary artery stenosis measured by instantaneous wave-free ratio (iFR) and the intraoperative transit time flow measurement (TTFM) of attached grafts as well as evaluate flow competition between the native coronary artery and the attached graft according to the severity of stenosis. <i>Materials and Methods:</i> In total, 89 grafts were subjected to intraoperative transit time flow measurement after coronary artery bypass grafting (CABG) in 25 patients with multivessel coronary artery disease (CAD). The iFR was evaluated for all coronary arteries with grafts. The coronary artery stenoses were divided into three groups based on the iFR value: iFR < 0.86 (group 1); iFR 0.86–0.90 (group 2); and iFR > 0.90 (group 3). <i>Results:</i> The mean graft flow (MGF) was 46.9 ± 18.4 mL/min for group 1, 45.3 ± 20.9 mL/min for group 2, and 31.3 ± 18.5 mL/min for group 3. A statistically significant difference was confirmed between groups 1 and 3 (<i>p</i> = 0.002) and between groups 2 and 3 (<i>p</i> = 0.025). The pulsatility index (PI) was 2.49 ± 1.20 for group 1, 2.66 ± 2.13 for group 2, and 4.70 ± 3.66 for group 3. A statistically significant difference was found between groups 1 and 3 (<i>p</i> = 0.006) and between groups 2 and 3 (<i>p</i> = 0.032). Backward flow was detected in 7.5% of grafts for group 1, in 16.6% of grafts for group 2, and in 16% of grafts for group 3. A statistically significant difference was found between groups 1 and 2 (<i>p</i> = 0.025) and between groups 1 and 3 (<i>p</i> = 0.029). <i>Conclusions:</i> The iFR is a useful tool for predicting the impact of competitive flow observed between a native artery and an attached graft. The effect of competitive flow significantly increases when the graft is attached to a vessel with mild coronary stenosis. In a coronary artery where the iFR was not hemodynamically significant, the MGF was lower, the PI was higher, and a larger proportion of grafts with backward flow (BF) was detected compared to when there was significant stenosis (iFR < 0.86). |
| first_indexed | 2024-03-12T11:16:29Z |
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| spelling | doaj.art-3f69f72927ac4c578ac4ac52be9381192023-09-02T01:57:20ZengMDPI AGMedicina1010-660X2020-12-015671471410.3390/medicina56120714Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached GraftsAlmas Tolegenuly0Rasa Ordiene1Arslan Mamedov2Ramunas Unikas3Rimantas Benetis4Department of Cardiac, Thoracic and Vascular Surgery, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, LT-50009 Kaunas, LithuaniaDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, LT-50009 Kaunas, LithuaniaDepartment of Cardiac, Thoracic and Vascular Surgery, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, LT-50009 Kaunas, LithuaniaDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, LT-50009 Kaunas, LithuaniaDepartment of Cardiac, Thoracic and Vascular Surgery, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Medical Academy, Lithuanian University of Health Sciences, Eivenių 2, LT-50009 Kaunas, Lithuania<i>Background and Objectives:</i> To assess the correlation between the degree of target coronary artery stenosis measured by instantaneous wave-free ratio (iFR) and the intraoperative transit time flow measurement (TTFM) of attached grafts as well as evaluate flow competition between the native coronary artery and the attached graft according to the severity of stenosis. <i>Materials and Methods:</i> In total, 89 grafts were subjected to intraoperative transit time flow measurement after coronary artery bypass grafting (CABG) in 25 patients with multivessel coronary artery disease (CAD). The iFR was evaluated for all coronary arteries with grafts. The coronary artery stenoses were divided into three groups based on the iFR value: iFR < 0.86 (group 1); iFR 0.86–0.90 (group 2); and iFR > 0.90 (group 3). <i>Results:</i> The mean graft flow (MGF) was 46.9 ± 18.4 mL/min for group 1, 45.3 ± 20.9 mL/min for group 2, and 31.3 ± 18.5 mL/min for group 3. A statistically significant difference was confirmed between groups 1 and 3 (<i>p</i> = 0.002) and between groups 2 and 3 (<i>p</i> = 0.025). The pulsatility index (PI) was 2.49 ± 1.20 for group 1, 2.66 ± 2.13 for group 2, and 4.70 ± 3.66 for group 3. A statistically significant difference was found between groups 1 and 3 (<i>p</i> = 0.006) and between groups 2 and 3 (<i>p</i> = 0.032). Backward flow was detected in 7.5% of grafts for group 1, in 16.6% of grafts for group 2, and in 16% of grafts for group 3. A statistically significant difference was found between groups 1 and 2 (<i>p</i> = 0.025) and between groups 1 and 3 (<i>p</i> = 0.029). <i>Conclusions:</i> The iFR is a useful tool for predicting the impact of competitive flow observed between a native artery and an attached graft. The effect of competitive flow significantly increases when the graft is attached to a vessel with mild coronary stenosis. In a coronary artery where the iFR was not hemodynamically significant, the MGF was lower, the PI was higher, and a larger proportion of grafts with backward flow (BF) was detected compared to when there was significant stenosis (iFR < 0.86).https://www.mdpi.com/1010-660X/56/12/714coronary artery bypass graftinginstantaneous wave-free ratiotransit time flow measurementcompetitive flowearly graft failure |
| spellingShingle | Almas Tolegenuly Rasa Ordiene Arslan Mamedov Ramunas Unikas Rimantas Benetis Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached Grafts Medicina coronary artery bypass grafting instantaneous wave-free ratio transit time flow measurement competitive flow early graft failure |
| title | Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached Grafts |
| title_full | Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached Grafts |
| title_fullStr | Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached Grafts |
| title_full_unstemmed | Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached Grafts |
| title_short | Correlation between Preoperative Coronary Artery Stenosis Severity Measured by Instantaneous Wave-Free Ratio and Intraoperative Transit Time Flow Measurement of Attached Grafts |
| title_sort | correlation between preoperative coronary artery stenosis severity measured by instantaneous wave free ratio and intraoperative transit time flow measurement of attached grafts |
| topic | coronary artery bypass grafting instantaneous wave-free ratio transit time flow measurement competitive flow early graft failure |
| url | https://www.mdpi.com/1010-660X/56/12/714 |
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