Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone
The objective was to elucidate the effects of dietary guanidinoacetic acid (GAA) supplementation on broiler performance, serum enzymes, oxidative biomarkers, mitochondrial activities, carcase traits, gross lesion of cardiac muscle and liver histopathology in broilers challenged with T3-hormone. A to...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/1828051X.2021.1901615 |
| _version_ | 1811297120550912000 |
|---|---|
| author | Shady Khalil Ahmed A. Al-Sagan Hossam A. Abdellatif Abdelbary Prince Ramadan El-Banna |
| author_facet | Shady Khalil Ahmed A. Al-Sagan Hossam A. Abdellatif Abdelbary Prince Ramadan El-Banna |
| author_sort | Shady Khalil |
| collection | DOAJ |
| description | The objective was to elucidate the effects of dietary guanidinoacetic acid (GAA) supplementation on broiler performance, serum enzymes, oxidative biomarkers, mitochondrial activities, carcase traits, gross lesion of cardiac muscle and liver histopathology in broilers challenged with T3-hormone. A total-of-192 one-day-old mixed sexed broilers were randomly assigned in a two factorial design, including two dietary treatments; control diet supplemented with or without T3-hormone (1.5 ppm) and GAA diet (0.06%) supplemented with or without T3-hormone (1.5 ppm). Each group was subdivided into eight replicates. Results showed interactions between GAAxT3-hormone. GAA diet significantly mitigated the negative effect of T3-hormone on serum total creatine kinase (CK), cardiac muscle (CK-MB), liver malondialdehyde (MDA) and superoxide dismutase (SOD), mitochondrial activities of cardiac muscle and liver histopathological lesion. In conclusion, GAA at a rate of 0.06% may have the potential to mitigate the negative effect of dietary T3-hormone but could not reduce the ascites mortality at such inclusion rate.HIGHLIGHTS GAA protected heart muscle. GAA mitigated the oxidative radicals in T3-hormone challenged birds. GAA modulated the mitochondrial activities in T3-hormone challenged birds. |
| first_indexed | 2024-04-13T05:59:22Z |
| format | Article |
| id | doaj.art-3f6a42c0bfc24e349888f1d38d9f18ae |
| institution | Directory Open Access Journal |
| issn | 1594-4077 1828-051X |
| language | English |
| last_indexed | 2024-04-13T05:59:22Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-3f6a42c0bfc24e349888f1d38d9f18ae2022-12-22T02:59:29ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2021-01-0120161162210.1080/1828051X.2021.19016151901615Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-HormoneShady Khalil0Ahmed A. Al-Sagan1Hossam A. Abdellatif2Abdelbary Prince3Ramadan El-Banna4Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Cairo UniversityKing Abdulaziz City for Science & TechnologyDepartment of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Biochemistry, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Cairo UniversityThe objective was to elucidate the effects of dietary guanidinoacetic acid (GAA) supplementation on broiler performance, serum enzymes, oxidative biomarkers, mitochondrial activities, carcase traits, gross lesion of cardiac muscle and liver histopathology in broilers challenged with T3-hormone. A total-of-192 one-day-old mixed sexed broilers were randomly assigned in a two factorial design, including two dietary treatments; control diet supplemented with or without T3-hormone (1.5 ppm) and GAA diet (0.06%) supplemented with or without T3-hormone (1.5 ppm). Each group was subdivided into eight replicates. Results showed interactions between GAAxT3-hormone. GAA diet significantly mitigated the negative effect of T3-hormone on serum total creatine kinase (CK), cardiac muscle (CK-MB), liver malondialdehyde (MDA) and superoxide dismutase (SOD), mitochondrial activities of cardiac muscle and liver histopathological lesion. In conclusion, GAA at a rate of 0.06% may have the potential to mitigate the negative effect of dietary T3-hormone but could not reduce the ascites mortality at such inclusion rate.HIGHLIGHTS GAA protected heart muscle. GAA mitigated the oxidative radicals in T3-hormone challenged birds. GAA modulated the mitochondrial activities in T3-hormone challenged birds.http://dx.doi.org/10.1080/1828051X.2021.1901615guanidinoacetic acidbroileroxidative biomarkermitochondriat3 hormone |
| spellingShingle | Shady Khalil Ahmed A. Al-Sagan Hossam A. Abdellatif Abdelbary Prince Ramadan El-Banna Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone Italian Journal of Animal Science guanidinoacetic acid broiler oxidative biomarker mitochondria t3 hormone |
| title | Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone |
| title_full | Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone |
| title_fullStr | Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone |
| title_full_unstemmed | Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone |
| title_short | Effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with T3-Hormone |
| title_sort | effects of guanidinoacetic acid supplementation on zootechnical performance and some biometric indices in broilers challenged with t3 hormone |
| topic | guanidinoacetic acid broiler oxidative biomarker mitochondria t3 hormone |
| url | http://dx.doi.org/10.1080/1828051X.2021.1901615 |
| work_keys_str_mv | AT shadykhalil effectsofguanidinoaceticacidsupplementationonzootechnicalperformanceandsomebiometricindicesinbroilerschallengedwitht3hormone AT ahmedaalsagan effectsofguanidinoaceticacidsupplementationonzootechnicalperformanceandsomebiometricindicesinbroilerschallengedwitht3hormone AT hossamaabdellatif effectsofguanidinoaceticacidsupplementationonzootechnicalperformanceandsomebiometricindicesinbroilerschallengedwitht3hormone AT abdelbaryprince effectsofguanidinoaceticacidsupplementationonzootechnicalperformanceandsomebiometricindicesinbroilerschallengedwitht3hormone AT ramadanelbanna effectsofguanidinoaceticacidsupplementationonzootechnicalperformanceandsomebiometricindicesinbroilerschallengedwitht3hormone |