Prostate Cancer Radiogenomics—From Imaging to Molecular Characterization

Prostate Cancer Radiogenomics—From Imaging to Molecular Characterization

Radiomics and genomics represent two of the most promising fields of cancer research, designed to improve the risk stratification and disease management of patients with prostate cancer (PCa). Radiomics involves a conversion of imaging derivate quantitative features using manual or automated algorit...

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Bibliographic Details
Main Authors: Matteo Ferro, Ottavio de Cobelli, Mihai Dorin Vartolomei, Giuseppe Lucarelli, Felice Crocetto, Biagio Barone, Alessandro Sciarra, Francesco Del Giudice, Matteo Muto, Martina Maggi, Giuseppe Carrieri, Gian Maria Busetto, Ugo Falagario, Daniela Terracciano, Luigi Cormio, Gennaro Musi, Octavian Sabin Tataru
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
radiomics
radiogenomics
genomics
prostate cancer
molecular characterization
MRI
Online Access:https://www.mdpi.com/1422-0067/22/18/9971
Description
Summary:Radiomics and genomics represent two of the most promising fields of cancer research, designed to improve the risk stratification and disease management of patients with prostate cancer (PCa). Radiomics involves a conversion of imaging derivate quantitative features using manual or automated algorithms, enhancing existing data through mathematical analysis. This could increase the clinical value in PCa management. To extract features from imaging methods such as magnetic resonance imaging (MRI), the empiric nature of the analysis using machine learning and artificial intelligence could help make the best clinical decisions. Genomics information can be explained or decoded by radiomics. The development of methodologies can create more-efficient predictive models and can better characterize the molecular features of PCa. Additionally, the identification of new imaging biomarkers can overcome the known heterogeneity of PCa, by non-invasive radiological assessment of the whole specific organ. In the future, the validation of recent findings, in large, randomized cohorts of PCa patients, can establish the role of radiogenomics. Briefly, we aimed to review the current literature of highly quantitative and qualitative results from well-designed studies for the diagnoses, treatment, and follow-up of prostate cancer, based on radiomics, genomics and radiogenomics research.
ISSN:1661-6596
1422-0067

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