Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00916/full |
| _version_ | 1818136748099633152 |
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| author | Ming-xin Cao Ya-ling Tang Wei-long Zhang Ya-Jie Tang Ya-Jie Tang Xin-hua Liang |
| author_facet | Ming-xin Cao Ya-ling Tang Wei-long Zhang Ya-Jie Tang Ya-Jie Tang Xin-hua Liang |
| author_sort | Ming-xin Cao |
| collection | DOAJ |
| description | Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established during embryogenesis, and has a close relationship with pathological conditions such as lymphatic developmental diseases, inflammation, and cancer. This review summarizes the molecular mechanisms of lymphangiogenesis in lymphatic development, inflammation and cancer metastasis, and discusses ncRNAs' regulatory effects on them. Therapeutic targets with regard to lymphangiogenesis are also discussed. |
| first_indexed | 2024-12-11T09:45:20Z |
| format | Article |
| id | doaj.art-3f6c1874b1f248e78bcda39afd8cbb08 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T09:45:20Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-3f6c1874b1f248e78bcda39afd8cbb082022-12-22T01:12:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-09-01910.3389/fonc.2019.00916460299Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer MetastasisMing-xin Cao0Ya-ling Tang1Wei-long Zhang2Ya-Jie Tang3Ya-Jie Tang4Xin-hua Liang5State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, ChinaHubei Key Laboratory of Industrial Microbiology, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei University of Technology, Wuhan, ChinaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaNon-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving from preexisting vessels, becomes established during embryogenesis, and has a close relationship with pathological conditions such as lymphatic developmental diseases, inflammation, and cancer. This review summarizes the molecular mechanisms of lymphangiogenesis in lymphatic development, inflammation and cancer metastasis, and discusses ncRNAs' regulatory effects on them. Therapeutic targets with regard to lymphangiogenesis are also discussed.https://www.frontiersin.org/article/10.3389/fonc.2019.00916/fullnon-coding RNA (ncRNA)lymphangiogenesislymphatic developmentinflammationcancer metastasis |
| spellingShingle | Ming-xin Cao Ya-ling Tang Wei-long Zhang Ya-Jie Tang Ya-Jie Tang Xin-hua Liang Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis Frontiers in Oncology non-coding RNA (ncRNA) lymphangiogenesis lymphatic development inflammation cancer metastasis |
| title | Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis |
| title_full | Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis |
| title_fullStr | Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis |
| title_full_unstemmed | Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis |
| title_short | Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis |
| title_sort | non coding rnas as regulators of lymphangiogenesis in lymphatic development inflammation and cancer metastasis |
| topic | non-coding RNA (ncRNA) lymphangiogenesis lymphatic development inflammation cancer metastasis |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00916/full |
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